Elevated serum neopterin and homocysteine increased the risk of ischemic stroke in patients with transient ischemic attack

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pteridines Pub Date : 2019-01-01 DOI:10.1515/pteridines-2019-0009

Jing Xie, Xia Qiu, Chunling Ji, Chun-Hong Liu, Yueming Wu

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引用次数: 2

Abstract

Abstract Objective: To investigate the correlation between serum neopterin, homocysteine (Hcy) and the risk of developing ischemic stroke (IS) in patients with transient ischemic attack (TIA). Methods: Ninety-two TIA patients were prospectively recruited at the First Affiliated Hospital of the Medical College, Shihezi University, Xinjiang Autonomous Region China. Of the included patients, 27 developed ischemic stroke (IS group) and other 65 cases did not (TIA group). Peripheral venous blood was obtained within 24 hours of TIA diagnosis. Serum neopterin, Hcy and serum lipid levels were tested and compared between IS and TIA groups. Results: Serum neopterin (6.38±1.76 ng/mL vs 5.39±1.51 ng/mL), Hcy (17.95±4.10 μmol/L vs 15.30±3.66 μmol/L), TG (1.82±0.92 mmol/L vs 1.40±0.71 mmol/L) and LDL (3.31±0.67 mmol/L vs 2.69±0.62 mmol/L) of IS group were significantly higher than those of TIA group (p<0.05). The AUC of serum neopterin, Hcy, TG and LDL for predicting the risk of developing IS in patients with TIA were 0.68 (95%CI: 0.55-0.81, 0.68 (95%CI: 0.57-0.80), 0.64 (95%CI: 0.51-0.78) and 0.75 (95%CI: 0.63-0.86), respectively. Conclusion: Serum neopterin, Hcy, TG and LDL are promising serological markers for predicting the increased risk of developing IS for patients with TIA.

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血清新蝶呤和同型半胱氨酸升高增加短暂性脑缺血发作患者发生缺血性脑卒中的风险

摘要目的：探讨短暂性脑缺血发作（TIA）患者血清新蝶呤、同型半胱氨酸（Hcy）与缺血性脑卒中（IS）发生风险的相关性。方法：在中国新疆自治区石河子大学医学院第一附属医院前瞻性招募92例TIA患者。在纳入的患者中，27例发生缺血性脑卒中（IS组），其他65例没有发生缺血性脑缺血（TIA组）。在TIA诊断后24小时内采集外周静脉血。检测IS组和TIA组的血清新蝶呤、Hcy和血脂水平并进行比较。结果：IS组血清新蝶呤（6.38±1.76 ng/mL vs 5.39±1.51 ng/mL）、Hcy（17.95±4.10μmol/L vs 15.30±3.66μmol/L）、TG（1.82±0.92 mmol/L vs 1.40±0.71 mmol/L）和LDL（3.31±0.67 mmol/L vs 2.69±0.62 mmol/L）均显著高于TIA组（p<0.05），TG和LDL预测TIA患者发展为IS的风险分别为0.68（95%CI:0.55-0.81，0.68（95%CI:0.57-0.80），0.64（95%CI=0.51-0.78）和0.75（95%CI0.63-0.86）。结论：血清新蝶呤、Hcy、TG和LDL是预测TIA患者发生IS风险增加的有前景的血清学标志物。

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来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.