Role of Smoking-Mediated molecular events in the genesis of oral cancers

IF 2.8 4区医学 Q2 TOXICOLOGY

Toxicology Mechanisms and Methods Pub Date : 2019-09-03 DOI:10.1080/15376516.2019.1646372

Sapna Khowal, S. Wajid

引用次数: 11

Abstract

Abstract Smoking is a pernicious practice prevalent worldwide. It involves breathing of burnt-tobacco fumes/smoke which comprises of numerous chemical entities posing deleterious aftermaths in the oral cavity. Tobacco fumes carry carcinogens and damaging chemicals like nitrosamines, polycyclic aromatic hydrocarbons, aldehydes, nicotine, phenols, carbon monoxides, radioactive elements, heavy metal ions. Oral cavity (mouth or buccal cavity), forming initial contacts with tobacco smokables, plays an essential role in the digestive system, facial determinations and speech. Smoking is a significant risk factor for oral cavity cancers. Nearly 50% of deaths from oral cavity cancer (oral cancer) attribute to smoking. This review intends to focus on the smoking mediated molecular modulations that are associated with the genesis of oral cancers.

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吸烟介导的分子事件在口腔癌发生中的作用

摘要吸烟是世界范围内普遍存在的有害行为。它涉及吸入燃烧过的烟草烟雾/烟雾，这些烟雾/烟雾由许多化学物质组成，在口腔中造成有害后果。烟草烟雾携带致癌物质和有害化学物质，如亚硝胺、多环芳烃、醛类、尼古丁、酚类、一氧化碳、放射性元素和重金属离子。口腔（口腔或颊腔）与烟草烟雾形成最初的接触，在消化系统、面部判断和言语中发挥着重要作用。吸烟是口腔癌的重要危险因素。口腔癌症（口腔癌症）的死亡近50%归因于吸烟。这篇综述旨在关注吸烟介导的与口腔癌发生相关的分子调节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicology Mechanisms and Methods TOXICOLOGY-

自引率

3.10%

发文量

期刊介绍： Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: In vivo studies with standard and alternative species In vitro studies and alternative methodologies Molecular, biochemical, and cellular techniques Pharmacokinetics and pharmacodynamics Mathematical modeling and computer programs Forensic analyses Risk assessment Data collection and analysis.