The Use of Zebrafish and in Vivo PAL as a Novel Discovery Platform for Psychoactive Agents

Q3 Pharmacology, Toxicology and Pharmaceutics

Jordan Journal of Pharmaceutical Sciences Pub Date : 2023-07-24 DOI:10.35516/jjps.v16i2.1498

F. Williams

引用次数: 1

Abstract

Our research is utilizing the zebrafish model to study molecular processes and animal models of human diseases. These studies discussed here start to assess how different bath salts and methamphetaminecause death upon overdose by addressing the molecules that may bind to the illicit drugs. We have accomplished this by developing an in vivo photo-affinity labelling (PAL) system and studying the drugs in our system. The zebrafish has been lauded as a unique and powerful tool to examine development in a vertebrate animal and address molecular aspects of human disease for decades. We will examine recent published data from our laboratory utilizing the PAL system we developed.

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斑马鱼和体内PAL作为精神活性剂新发现平台的应用

我们的研究利用斑马鱼模型来研究人类疾病的分子过程和动物模型。这里讨论的这些研究开始评估不同的浴盐和甲基苯丙胺如何通过解决可能与非法药物结合的分子而导致过量死亡。我们通过开发体内光亲和标记（PAL）系统和研究系统中的药物来实现这一目标。几十年来，斑马鱼一直被誉为研究脊椎动物发育和解决人类疾病分子方面问题的独特而强大的工具。我们将利用我们开发的PAL系统检查实验室最近公布的数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jordan Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： The Jordan Journal of Pharmaceutical Sciences (JJPS) is a scientific, bi-annual, peer-reviewed publication that will focus on current topics of interest to the pharmaceutical community at large. Although the JJPS is intended to be of interest to pharmaceutical scientists, other healthy workers, and manufacturing processors will also find it most interesting and informative. Papers will cover basic pharmaceutical and applied research, scientific commentaries, as well as views, reviews. Topics on products will include manufacturing process, quality control, pharmaceutical engineering, pharmaceutical technology, and philosophies on all aspects of pharmaceutical sciences. The editorial advisory board would like to place an emphasis on new and innovative methods, technologies, and techniques for the pharmaceutical industry. The reader will find a broad range of important topics in this first issue.