Research progress in metronomic photodynamic therapy

国际生物医学工程杂志 Pub Date : 2019-06-28 DOI:10.3760/CMA.J.ISSN.1673-4181.2019.03.015

Xiafei Shi, Yingxin Li, W. Jin

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Abstract

Metronomic photodynamic therapy (mPDT) is a new type of photodynamic therapy (PDT) that has received much attention in recent years. It has a similar therapeutic mechanism to traditional PDT, i.e. the photosensitizer is irradiated by visible light irradiation with a specific wavelength, and tissue oxygen photochemical reactions produce cytotoxic reactive oxygen species (ROS) that selectively kill rapidly proliferating tumor cells. Unlike traditional PDT, the photosensitizer and light in mPDT are continuously transmitted at a low time and at a low rate, and the specificity of tumor treatment is enhanced by apoptosis. In this paper, the current researches on the in vitro and in vivo effects and mechanisms of mPDT, as well as the research status of photosensitizers and light sources for in vivo research, were reviewed, with a view to understanding the existing mPDT technology and providing reference for the further studies. This review paper can provide a basic for promoting the clinical research and application of mPDT. Key words: Metronomic photodynamic therapy; Photosensitizers; Light sources; Brain tumor; 5-aminolevulinic acid

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节律光动力疗法的研究进展

计量光动力疗法（mPDT）是近年来备受关注的一种新型光动力疗法。它具有与传统PDT类似的治疗机制，即光敏剂通过特定波长的可见光照射，组织氧光化学反应产生细胞毒性活性氧（ROS），选择性杀死快速增殖的肿瘤细胞。与传统的PDT不同，mPDT中的光敏剂和光以低时间、低速率连续传输，细胞凋亡增强了肿瘤治疗的特异性。本文综述了目前mPDT在体外和体内的作用和机制的研究进展，以及用于体内研究的光敏剂和光源的研究现状，以期了解现有的mPDT技术，为进一步的研究提供参考。这篇综述论文可以为促进mPDT的临床研究和应用提供基础。关键词：节拍光动力疗法；光敏剂；光源；脑肿瘤；5-氨基乙酰丙酸

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国际生物医学工程杂志

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1974