Evaluation of the Correlation of Pulmonary Arterial Hypertension (PAH) with the Pulmonary Artery Trunk Diameter and Serum Level of N-Terminal Pro B-Type Natriuretic Peptide (NT-proBNP) in Patients with PAH

IF 0.2 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Iranian Journal of Radiology Pub Date : 2023-07-11 DOI:10.5812/iranjradiol-133022

S. Gharibi, M. Ghavami, Hamid Khederlou, Seyyed Mojtaba Ghorashi, S. Dabiran, Fahime Zeinalkhani

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引用次数: 0

Abstract

Background: Due to its non-specific symptoms, pulmonary arterial hypertension (PAH) is difficult to diagnose via non-invasive methods. Various diagnostic tests are required to evaluate PAH patients. The increased diameter of the main pulmonary artery in computed tomography (CT) imaging represents a high probability of PAH. Moreover, N-terminal pro B-type natriuretic peptide (NT-proBNP) and pro B-type natriuretic peptide (proBNP) can be considered as prognostic predictors in patients with PAH. Objectives: This study aimed to evaluate the correlation of CT-based main pulmonary artery diameter (MPAD) and the serum level of NT-proBNP (as a strong pro-inflammatory factor) with the severity of PAH in echocardiography among patients with PAH. Patients and Methods: In this cross-sectional study, a total of 63 hospitalized patients with PAH due to chronic obstructive pulmonary disease were recruited from 2019 to 2020 after initial evaluations and collection of serum NT-proBNP measurements and echocardiographic findings. On the chest CT scans, the largest diameter of the pulmonary artery trunk was determined, and then, correlation of CT-based MPAD with both PAH severity on echocardiography and NT-proBNP level in patients with PAH were evaluated. Results: The results of the present study on 63 patients (70% male; mean age, 67.02 years) showed a significant positive correlation between the MPAD and NT-proBNP level (r = 0.444, P < 0.001). Moreover, a significant positive relationship was observed between the pulmonary artery pressure (PAP) and NT-proBNP (r = 0.353, P = 0.005) and also between MPAD and PAP (r = 0.306, P = 0.015). In PAH patients, the mean values of MPAD, PAP, and NT-proBNP were 32.58 mm, 47.9 mmHg, and 6563 pg/mL, respectively. Conclusion: Considering the significant positive correlation between PAP, MPAD, and NT-proBNP level in subgroup comparisons based on MPAD and PAP, if the MPAD is abnormal on CT scan, additional echocardiographic assessments and serum NT-proBNP measurements can be helpful.

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肺动脉高压(PAH)与肺动脉干直径及血清n端亲b型利钠肽(NT-proBNP)水平的相关性评价

背景：肺动脉高压（PAH）由于其非特异性症状，难以通过非侵入性方法进行诊断。需要进行各种诊断测试来评估PAH患者。在计算机断层扫描（CT）成像中，肺主动脉直径的增加代表PAH的高概率。此外，N-末端B型利钠肽原（NT-proBNP）和B型利钠肽原（proBNP）可被认为是PAH患者的预后预测因子。目的：本研究旨在评估肺动脉高压患者超声心动图中基于CT的肺主动脉直径（MPAD）和血清NT-proBNP（一种强促炎因子）水平与肺动脉高压严重程度的相关性。患者和方法：在这项横断面研究中，在初步评估和收集血清NT-proBNP测量结果和超声心动图检查结果后，从2019年到2020年，共招募了63名因慢性阻塞性肺病而住院的PAH患者。在胸部CT扫描中，确定肺动脉干的最大直径，然后评估基于CT的MPAD与PAH患者超声心动图上PAH严重程度和NT-proBNP水平的相关性。结果：63例患者（70%为男性，平均年龄67.02岁）MPAD与NT-proBNP水平呈正相关（r=0.444，P<0.001），肺动脉压（PAP）与NT-proBNP呈显著正相关（r=0.353，P=0.005），MPAD与PAP呈正相关（r=0.306，P=0.015）。结论：考虑到在基于MPAD和PAP的亚组比较中，PAP、MPAD和NT-proBNP水平之间存在显著的正相关性，如果MPAD在CT扫描中异常，额外的超声心动图评估和血清NT-proBNP测量可能会有所帮助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Radiology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

0.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Iranian Journal of Radiology is the official journal of Tehran University of Medical Sciences and the Iranian Society of Radiology. It is a scientific forum dedicated primarily to the topics relevant to radiology and allied sciences of the developing countries, which have been neglected or have received little attention in the Western medical literature. This journal particularly welcomes manuscripts which deal with radiology and imaging from geographic regions wherein problems regarding economic, social, ethnic and cultural parameters affecting prevalence and course of the illness are taken into consideration. The Iranian Journal of Radiology has been launched in order to interchange information in the field of radiology and other related scientific spheres. In accordance with the objective of developing the scientific ability of the radiological population and other related scientific fields, this journal publishes research articles, evidence-based review articles, and case reports focused on regional tropics. Iranian Journal of Radiology operates in agreement with the below principles in compliance with continuous quality improvement: 1-Increasing the satisfaction of the readers, authors, staff, and co-workers. 2-Improving the scientific content and appearance of the journal. 3-Advancing the scientific validity of the journal both nationally and internationally. Such basics are accomplished only by aggregative effort and reciprocity of the radiological population and related sciences, authorities, and staff of the journal.