Development of cellulosic-based hemostatic dressing with antibacterial activity

IF 2.3 4区管理学 Q1 MATERIALS SCIENCE, TEXTILES

Fashion and Textiles Pub Date : 2022-09-25 DOI:10.1186/s40691-022-00305-9

Mostafa Goodarz, Amir Behzadnia, Hassan Mohammadi

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Abstract

A cotton-based hemostatic dressing featuring antibacterial properties was developed with the potential of being used in traffic accidents to control hemorrhage. Cotton gauze was oxidized initially in an acidic medium and then coated by PVA nanofibers and/or PVA nanofibers loaded with Ciprofloxacin. Fabricated dressings were characterized by FTIR analysis and SEM images. The FTIR spectrum showed the existence of carboxyl groups on the oxidized cotton gauze's surface. The carboxyl groups content was estimated to be 17.3 ± 0.3 for the oxidized sample with a mixture of nitric acid and phosphoric acid for 24 h (OCF-Mixed acid24). Moreover, the effect of the exposure duration of cotton gauze in the acidic medium on the blood coagulation activity was assessed. It was observed that the OCF-Mixed acid24 sample exhibited an agreeable hemostatic activity (BCIs = 10). The antibacterial activity against E. coli and S. aureus bacteria was also captured for the coated cotton gauze by the PVA nanofibers loaded with Ciprofloxacin.

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具有抗菌活性的纤维素基止血敷料的研制

开发了一种具有抗菌性能的棉基止血敷料，具有在交通事故中控制出血的潜力。首先在酸性介质中氧化棉纱，然后用PVA纳米纤维和/或负载环丙沙星的PVA纳米纤维包覆棉纱。用FTIR和SEM对敷料进行了表征。红外光谱分析表明，氧化棉纱网表面存在羧基。用硝酸和磷酸混合24 h (OCF-Mixed acid24)氧化样品，羧基含量估计为17.3±0.3。此外，还评估了棉纱布在酸性介质中暴露时间对凝血活性的影响。观察到ocf -混合酸24样品具有良好的止血活性(bci = 10)。采用环丙沙星负载的聚乙烯醇纳米纤维包被棉纱，并对大肠杆菌和金黄色葡萄球菌进行了抑菌活性测定。

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来源期刊

Fashion and Textiles Business, Management and Accounting-Marketing

CiteScore

4.40

自引率

4.20%

发文量

审稿时长

13 weeks

期刊介绍： Fashion and Textiles aims to advance knowledge and to seek new perspectives in the fashion and textiles industry worldwide. We welcome original research articles, reviews, case studies, book reviews and letters to the editor. The scope of the journal includes the following four technical research divisions: Textile Science and Technology: Textile Material Science and Technology; Dyeing and Finishing; Smart and Intelligent Textiles Clothing Science and Technology: Physiology of Clothing/Textile Products; Protective clothing ; Smart and Intelligent clothing; Sportswear; Mass customization ; Apparel manufacturing Economics of Clothing and Textiles/Fashion Business: Management of the Clothing and Textiles Industry; Merchandising; Retailing; Fashion Marketing; Consumer Behavior; Socio-psychology of Fashion Fashion Design and Cultural Study on Fashion: Aesthetic Aspects of Fashion Product or Design Process; Textiles/Clothing/Fashion Design; Fashion Trend; History of Fashion; Costume or Dress; Fashion Theory; Fashion journalism; Fashion exhibition.