The new trend in the treatment of experimental cryptosporidiosis and the resulting intestinal dysplasia

IF 2.7 Q3 ONCOLOGY

Colorectal Cancer Pub Date : 2018-12-01 DOI:10.2217/CRC-2018-0008

N. Mostafa, Enas F Abdel Hamed, E. Fawzy, R. Zalat, H. Rashed, S. Mohamed

引用次数: 10

Abstract

Aim: Cryptosporidiosis causes colon dysplasia. This research aimed to evaluate the effect of a novel combination between artesunate and nitazoxanide on intensity of infection and the resulting intestinal dysplasia. Materials & methods: Subjects were divided into five groups. Artesunate was used alone, then combined with nitazoxanide. Results: The highest efficacy in reducing oocyst shedding obtained from the combined therapy (68.5, 75.9, 99%) after 7, 14 and 21 days. The histopathology of infected colonic mucosa showed marked improvement and low-grade of dysplasia in the infected and treated group with the combined therapy. The immunohistochemistry of the same group revealed mild dysplastic changes in colonic epithelium without nuclear expression for cyclin D1. Conclusion: These results give hope for treatment of Cryptosporidium and improving intestinal dysplasia.

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实验性隐孢子虫病及其引起的肠道发育不良治疗的新趋势

目的:隐孢子虫病引起结肠发育不良。本研究旨在评估青蒿琥酯和硝唑昔尼特的新组合对感染强度和由此引起的肠道发育不良的影响。材料与方法:受试者分为五组。单独使用青蒿琥酯，然后与硝唑尼特联合使用。结果:联合用药7、14、21 d时减少卵囊脱落的效果最高，分别为68.5、75.9、99%。感染组和治疗组经联合治疗后，感染结肠黏膜组织病理学明显改善，发育不良程度较低。免疫组化结果显示结肠上皮轻度发育异常，细胞周期蛋白D1无核表达。结论:本研究结果为隐孢子虫病的治疗和肠道发育不良的改善带来了希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colorectal Cancer ONCOLOGY-

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期刊介绍： Colorectal cancer is a major cause of morbidity and mortality, particularly in the developed world. Risk factors for colorectal cancer are on the rise in many countries; populations are aging, and obesity and diabetes are increasing. National screening programs are helping to detect cancer while it is still curable; however, colorectal cancer remains the third leading cause of cancer deaths in the USA and options are still limited for those with more advanced disease. Consequently, colorectal cancer is a major research priority for government, pharmaceutical companies and non-profit organizations. Research into diagnosis and optimum treatment of the disease is progressing rapidly, with new advances reported every day. Colorectal Cancer presents reviews, analysis and commentary. on all aspects of colorectal cancer.