Building In Silico Models to Trigger Retesting: A Strategy on How to Use Predictive Models to Identify Potentially Incorrect In Vitro Intrinsic Clearance Results

Q2 Health Professions

Applied In Vitro Toxicology Pub Date : 2019-06-17 DOI:10.1089/AIVT.2018.0018

SteinmetzFabian Pitter, PeterssonCarl, ZanelliUgo, CzodrowskiPaul

引用次数: 2

Abstract

Abstract Introduction: The results from biological assays, such as microsomal intrinsic clearance, are often associated with moderate to high variability. Nevertheless, it is crucial to disciplines...

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建立硅模型触发重新测试:如何使用预测模型来识别可能不正确的体外固有清除结果的策略

摘要:生物检测的结果，如微粒体固有清除率，通常与中度到高度变异性相关。然而，这对学科来说是至关重要的……

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来源期刊

Applied In Vitro Toxicology Health Professions-Medical Laboratory Technology

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Applied In Vitro Toxicology is a peer-reviewed journal providing the latest research on the application of alternative in vitro testing methods for predicting adverse effects in the pharmaceutical, chemical, and personal care industries. This Journal aims to address important issues facing the various chemical industries, including regulatory requirements; the reduction, refinement, and replacement of animal testing; new screening methods; evaluation of new cell and tissue models; and the most appropriate methods for assessing safety and satisfying regulatory demands. The Journal also delivers the latest views and opinions of developers of new models, end users of the models, academic laboratories that are inventing new tools, and regulatory agencies in the United States, Europe, Latin America, Australia and Asia. Applied In Vitro Toxicology is the journal that scientists involved with hazard identification and risk assessment will read to understand how new and existing in vitro methods are applied, and the questions for which these models provide answers. Applied In Vitro Toxicology coverage includes: -Applied in vitro toxicology industry standards -New technologies developed for applied in vitro toxicology -Data acquisition, cleaning, distribution, and best practices -Data protection, privacy, and policy -Business interests from research to product -The changing role of in vitro toxicology -Visualization and design principles of applied in vitro toxicology infrastructures -Physical interfaces and robotics -Opportunities around applied in vitro toxicology