The Potential Genotoxic Effects of Antineoplastic Drugs in Occupationally Exposed Nurses

Asia Pacific Journal of Medical Toxicology Pub Date : 2020-06-01 DOI:10.22038/APJMT.2020.16388

H. Fakher, Eslam S. Metwally, Rabab El-Shafey

{"title":"The Potential Genotoxic Effects of Antineoplastic Drugs in Occupationally Exposed Nurses","authors":"H. Fakher, Eslam S. Metwally, Rabab El-Shafey","doi":"10.22038/APJMT.2020.16388","DOIUrl":null,"url":null,"abstract":"Background: Antineoplastic drugs are commonly used globally. They directly interact with the tumor cell deoxyribonucleic acid and inhibit their growth. These actions are non-selectiveaffecting both tumor cells and healthy cells producing toxic effects. The present study was designed to evaluate oxidative stress and genotoxic effects of antineoplastic drugs in occupationally exposed nurses under routine working conditions. Methods: The studied groups included 28 nurses working in Hematology and Oncology unit, Benha University Hospitals and 20 non exposed subjects that work in academic jobs in Benha Faculty of Medicine, matched in age, gender & socioeconomic status. Malondoaldehyde (MDA) & reduced glutathione (GSH) were measured for all participants as markers of oxidative stress. Extent of DNA damage in leucocytes was also evaluated by comet assay as a biomarker of genotoxicity. Results: There were a significant increase in MDA & reduction in GSH in occupationally exposed subjects than control. Also, extent of DNA damage in the lymphocytes of occupationally exposed participants has a high significance than the controls. The work duration and age had a significant impact on degree of DNA damage. Conclusion: occupationally exposed nurses to antineoplastic agents are at greater risk of oxidative stress with consequent DNA damage and potential genotoxic damage.","PeriodicalId":30463,"journal":{"name":"Asia Pacific Journal of Medical Toxicology","volume":"9 1","pages":"60-66"},"PeriodicalIF":0.0000,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asia Pacific Journal of Medical Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22038/APJMT.2020.16388","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 1

Abstract

Background: Antineoplastic drugs are commonly used globally. They directly interact with the tumor cell deoxyribonucleic acid and inhibit their growth. These actions are non-selectiveaffecting both tumor cells and healthy cells producing toxic effects. The present study was designed to evaluate oxidative stress and genotoxic effects of antineoplastic drugs in occupationally exposed nurses under routine working conditions. Methods: The studied groups included 28 nurses working in Hematology and Oncology unit, Benha University Hospitals and 20 non exposed subjects that work in academic jobs in Benha Faculty of Medicine, matched in age, gender & socioeconomic status. Malondoaldehyde (MDA) & reduced glutathione (GSH) were measured for all participants as markers of oxidative stress. Extent of DNA damage in leucocytes was also evaluated by comet assay as a biomarker of genotoxicity. Results: There were a significant increase in MDA & reduction in GSH in occupationally exposed subjects than control. Also, extent of DNA damage in the lymphocytes of occupationally exposed participants has a high significance than the controls. The work duration and age had a significant impact on degree of DNA damage. Conclusion: occupationally exposed nurses to antineoplastic agents are at greater risk of oxidative stress with consequent DNA damage and potential genotoxic damage.

查看原文本刊更多论文

抗肿瘤药物对职业暴露护士的潜在基因毒性作用

背景：抗肿瘤药物在全球范围内普遍使用。它们直接与肿瘤细胞脱氧核糖核酸相互作用并抑制其生长。这些作用是非选择性的，对肿瘤细胞和健康细胞都有影响，产生毒性作用。本研究旨在评估在常规工作条件下，职业暴露护士中抗肿瘤药物的氧化应激和遗传毒性作用。方法：研究组包括28名在本哈大学医院血液和肿瘤科工作的护士，以及20名在本哈医学院从事学术工作的非暴露受试者，年龄、性别和社会经济地位匹配。测量所有参与者的丙二醛（MDA）和还原型谷胱甘肽（GSH）作为氧化应激的标志物。彗星试验还评估了白细胞DNA损伤的程度，作为遗传毒性的生物标志物。结果：与对照组相比，职业暴露受试者的MDA显著增加，GSH显著减少。此外，职业暴露参与者淋巴细胞中DNA损伤的程度比对照组具有更高的意义。工作时间和年龄对DNA损伤程度有显著影响。结论：职业接触抗肿瘤药物的护士面临更大的氧化应激风险，随之而来的是DNA损伤和潜在的遗传毒性损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Asia Pacific Journal of Medical Toxicology

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： Asia Pacific Journal of Medical Toxicology (APJMT) aims to expand the knowledge of medical toxicology and tries to provide reliable information in this field for medical and healthcare professionals. APJMT mainly focuses on research related to medical toxicology issues in the Asia Pacific region and publishes articles on clinical and epidemiological aspects of toxicology, poisonings emergency care, addiction, drug interactions and adverse effects. The journal accepts and welcomes high quality papers in the form of original articles and rarely review articles, case reports and scientific letters relevant to medical practice in toxicology.