Isotretinoin: an updated review on the profile of its side-effects and the management

Abstract

Acne vulgaris is a chronic inflammatory disorder of the skin, which presents as comedones, papules, pustules, nodules, and cysts. Based on the multifactorial pathogenesis, a range of treatment options exists. Isotretinoin is a wonder drug commonly used in the management of acne. Unfortunately, it is associated with specific adverse effects on account of the ubiquitous nature of the retinoic acid receptors, which regulate its mechanism of action. Majorly, these side effects are mild and can be taken care of by altering the dose or frequency. Severe side effects need more attention and have to be recognized early. The present article pertinently focuses on the side-effect profile of the drug isotretinoin and the management of those side effects for safer treatment of acne vulgaris.