Structural characterization of water-soluble polysaccharides from Sophora flavescens Ait. and their anti-inflammatory activities based on NO release

IF 1.2 4区化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Carbohydrate Chemistry Pub Date : 2022-01-01 DOI:10.1080/07328303.2023.2174551

Yi-Xuan Li , Bo-Wen Lu , Si-Liang Jiang , Cai-Xia Dong , Juan Du

引用次数: 0

Abstract

Sophora flavescens Ait. is a medicinal herb traditionally used to treat inflammatory diseases. In this study, four polysaccharides, SFNP-1, SFNP-2, SFAP-1, and SFAP-2, were isolated from S. flavescens. Both SFNP-1 and SFNP-2 were (1→4)-linked glucans. SFAP-1 and SFAP-2 were identified as pectin-type polysaccharides containing mainly a homo-galacturanan backbone (as shown). NO release inhibition test revealed that the major polysaccharides, SFAP-1 and SFAP-2, did not have a significant anti-inflammatory effect. This result suggests that the anti-inflammatory effect of S. flavescens may not depend on its polysaccharides.

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苦参水溶性多糖的结构表征。以及基于NO释放的抗炎活性

苦参是传统上用于治疗炎症性疾病的草药。本研究从黄参中分离得到4种多糖，分别为SFNP-1、SFNP-2、srap -1和srap -2。SFNP-1和SFNP-2均为(1→4)链葡聚糖。srap -1和srap -2被鉴定为果胶型多糖，主要含有同型半乳糖聚糖骨架(如图所示)。NO释放抑制试验显示，srap -1和srap -2主要多糖无明显的抗炎作用。提示黄参的抗炎作用可能不依赖于其多糖。下载:下载高清图片(12KB)下载:下载全尺寸图片

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来源期刊

Journal of Carbohydrate Chemistry 化学-生化与分子生物学

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Carbohydrate Chemistry serves as an international forum for research advances involving the chemistry and biology of carbohydrates. The following aspects are considered to fall within the scope of this journal: -novel synthetic methods involving carbohydrates, oligosaccharides, and glycoconjugates- the use of chemical methods to address aspects of glycobiology- spectroscopic and crystallographic structure studies of carbohydrates- computational and molecular modeling studies- physicochemical studies involving carbohydrates and the chemistry and biochemistry of carbohydrate polymers.