THE EFFECT OF BISPHOSPHONATE RISEDRONATE HYDROGEL ON ALKALINE PHOSPHATASE AND OSTEOCLASTS DURING RELAPSE MOVEMENT

Q3 Dentistry

Cumhuriyet Dental Journal Pub Date : 2022-04-05 DOI:10.7126/cumudj.932462

T. R. Utari, P. Pudyani, I. Ana, W. Asmara

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Abstract

Objectives: To analyze the effect of risedronate hydrogel on enzyme alkaline phosphatase (ALP) and osteoclast/osteoblast ratio during tooth relapse movement Materials and methods: The research design is experimental with time series. The lower incisors of 75 guinea pigs are distally moved using open coil spring. The guinea pigs were divided into three groups: without risedronate (group A; n = 25); given 250 µmol/L of risedronate hydrogel (group B; n = 25), and given 500 µmol/L of risedronate hydrogel (group C; n = 25). Risedronate were applied intrasulcularly in the mesial part of the gingival sulcus every 3 days. After 14 days of stabilization, the open coil spring was removed (bisphosphonate administration was continued). The relapsed teeth and ALP levels on days 0, 3, 7, 14, and 21 were measured. The osteoclast/osteoblast ratio was measured by hematoxylin and eosin staining. ANOVA test was used to determine the difference in the three groups and their interactions with concentration and time. Results: There was a significant difference in osteoclast/osteoblast ratio on day 3 (p = 0.019, p

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二膦酸-利塞膦酸盐水凝胶对复发运动过程中碱性磷酸酶和破骨细胞的影响

目的：分析利塞膦酸盐水凝胶对牙齿复发运动过程中碱性磷酸酶（ALP）和破骨细胞/成骨细胞比例的影响材料和方法：研究设计采用时间序列实验。75只豚鼠的下切牙使用开放式螺旋弹簧向远端移动。豚鼠分为三组：不含利塞膦酸盐（A组；n=25）；给予250µmol/L的利塞膦酸盐水凝胶（B组；n=25），以及给予500µmol/L的利塞膦酸盐水凝胶（C组，n=25）。利塞膦酸盐每隔3天在牙龈沟的近中部分进行一次沟内施用。稳定14天后，取出开放式螺旋弹簧（继续给予双磷酸盐）。测量第0、3、7、14和21天的复发牙齿和ALP水平。通过苏木精和伊红染色测定破骨细胞/成骨细胞比率。方差分析检验用于确定三组的差异及其与浓度和时间的相互作用。结果：第3天破骨细胞/成骨细胞的比例有显著差异（p=0.019，p

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