Gender difference in retrieval-extinction of conditioned fear memory

IF 1.3 4区心理学 Q3 PSYCHOLOGY, MULTIDISCIPLINARY

心理学报 Pub Date : 2021-10-25 DOI:10.3724/sp.j.1041.2021.01082

Wei Chen, Xiaoyi Lin, Junjiao Li, Wenxi Zhang, Nan Sun, Xifu Zheng

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引用次数: 2

Abstract

successfully suppressed the spontaneous fear recovery. Nevertheless, there was a significant gender difference in the reinstatement test, in which men showed increased skin conductance responses (SCR), whereas women did not show any increased SCR. Besides, there were gender differences in the spontaneous fear recovery and reinstatement test of the standard extinction paradigm. After training by this paradigm, women showed increased SCR in spontaneously fear recovery and a tendency to fear generalization. In contrast, men showed suppressed spontaneous fear recovery but showed increased SCR in the reinstatement test. Our study proved a gender difference in the extinction effect of the retrieval-extinction paradigm (women showed the best extinction effect) and verified that the extinction effect of the retrieval-extinction paradigm was better than that of the standard extinction paradigm. From the results, we could demonstrate that the retrieval-extinction paradigm is an effective intervention method, especially for women. It will be beneficial to further verify evidence about the effectiveness of the retrieval-extinction paradigm and clarify its object and scope in clinical applications. Our study suggests that the retrieval-extinction paradigm in clinical transformation needs to provide more personalized treatment plans for male and female patients, thus improving clinical applicability and treatment effectiveness.

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条件恐惧记忆检索消退的性别差异

成功地抑制了自发的恐惧恢复。然而，在恢复测试中存在显著的性别差异，男性表现出增加的皮肤电导反应(SCR)，而女性没有表现出任何增加的SCR。此外，在标准消退范式的自发恐惧恢复和恢复测试中，存在性别差异。经过这种模式的训练后，女性在自发的恐惧恢复和恐惧泛化倾向中表现出增加的SCR。相比之下，男性表现出抑制自发的恐惧恢复，但在恢复测试中表现出增加的SCR。本研究证实了检索-消失范式的消失效果存在性别差异(女性表现出最好的消失效果)，并验证了检索-消失范式的消失效果优于标准消失范式。从研究结果可以看出，检索-消失范式是一种有效的干预方法，尤其是对女性。这将有助于进一步验证检索-消失范式的有效性，明确其在临床应用中的对象和范围。我们的研究提示，临床转化中的检索-消失范式需要为男女患者提供更多个性化的治疗方案，从而提高临床适用性和治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

心理学报 Psychology-Psychology (all)

CiteScore

1.70

自引率

13.30%

发文量

1612

期刊介绍： Acta Psychologica Sinica (ISSN 0439-755X) is a scholarly journal sponsored by the Chinese Psychological Society and the Institute of Psychology, Chinese Academy of Sciences, and published monthly by the Science Press. Acta Psychologica Sinica has been included in many important national and international indexing systems such as SCOPUS (Elsevier), ESCI (Web of Science), PsycINFO (APA), CSCD. It is the flagship journal of the Chinese Psychological Society that publishes peer-reviewed original empirical studies and theoretical articles spanning the entire spectrum of scientific psychology. Acta Psychologica Sinica publishes high-quality research that investigates the fundamental mechanisms of mind and behavior and aims to deliver scientific knowledge to enhance our understanding of culture and society. It welcomes submissions of manuscripts reporting research that is up-to-date, scientifically excellent, and of broad interest and significance.