64Cu production by 14 MeV neutron beam

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2020-10-20 DOI:10.3233/jnr-190140

M. Capogni, M. Capone, A. Pietropaolo, A. Fazio, G. Dellepiane, R. Falconi, A. Colangeli, S. Palomba, G. Valentini, M. Fantuzi, R. Faccini, A. Pizzuto

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引用次数: 2

Abstract

64Cu is an emerging radionuclide of great interest in personalized nuclear medicine. It is produced by a cyclotron via the reaction 64Ni(p,n)64Cu. This production method increased during the last decades, because small biomedical cyclotrons can be easily installed close to the nuclear medicine department of a hospital. As a matter of fact, 64Ni is a very expensive target material. For this reason, an alternative 64Cu production method was investigated at ENEA by using the quasi-monochromatic 14 MeV fusion neutron beam made available at the Frascati Neutron Generator (FNG) located at the ENEA – Frascati Research Center. In particular, two nuclear reactions were studied: 65Cu(n,2n)64Cu and 64Zn(n,p)64Cu. The radiochemical analysis of the activated samples was performed at the ENEA-NMLNWM laboratory located in ENEA-Casaccia Research Center. The activity measurements were carried out at the ENEA-INMRI, located in the ENEA-Casaccia Research Center, with high metrological level conditions and by assuring their traceability to the 64Cu primary activity standard here developed and maintained. A prediction of the 64Cu production by means of the high-brilliance 14 MeV neutron source named Sorgentina is also discussed.

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14mev中子束产生64Cu

64Cu是一种新兴的放射性核素，在个性化核医学中引起了极大的兴趣。它是由回旋加速器通过64Ni(p,n)64Cu反应产生的。这种生产方法在过去几十年里有所增加，因为小型生物医学回旋加速器可以很容易地安装在医院核医学部门附近。事实上，64Ni是一种非常昂贵的靶材料。因此，ENEA研究人员利用位于ENEA - Frascati研究中心的Frascati中子发生器(FNG)提供的准单色14 MeV聚变中子束，研究了另一种64Cu生产方法。特别研究了65Cu(n,2n)64Cu和64Zn(n,p)64Cu两种核反应。活化样品的放射化学分析在位于ENEA-Casaccia研究中心的ENEA-NMLNWM实验室进行。活度测量是在ENEA-INMRI进行的，位于ENEA-Casaccia研究中心，具有高计量水平条件，并确保其可追溯性符合这里开发和维护的64Cu主要活度标准。本文还讨论了利用高亮度14mev中子源Sorgentina对64Cu产量的预测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.