Serotonin Syndrome after a Single Dose of Sertraline: A Case Report

Abstract

Backgrounds: Serotonin Syndrome is a rare and life-threatening drug reaction that occurs with increased serotonin activity in the brain as a result of taking therapeutic doses or excessive amounts of serotonergic-acting drugs or using multiple serotonergic-acting drugs together. It is characterized by neuromuscular abnormalities, autonomic hyperactivity, and cognitive/behavioral changes. Case: In our case, we describe a serotonergic syndrome, which developed as a result of the use of a therapeutic single dose serotonergic drug in a 15-year-old girl and its treatment. Conclusions: The determination of the history of serotonergic drug use, early recognition of the mental, autonomic, and neurological finding triad, and the early application of supportive medical treatments ensure the effective and successful management of the case.