Insight to Biofabrication of Liver Microtissues for Disease Modeling: Challenges and Opportunities.

Hengameh Dortaj, Negar Azarpira, Sara Pakbaz
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Abstract

In the last decade, liver diseases with high mortality rates have become one of the most important health problems in the world. Organ transplantation is currently considered the most effective treatment for compensatory liver failure. An increasing number of patients and shortage of donors has led to the attention of reconstructive medicine methods researchers. The biggest challenge in the development of drugs effective in chronic liver disease is the lack of a suitable preclinical model that can mimic the microenvironment of liver problems. Organoid technology is a rapidly evolving field that enables researchers to reconstruct, evaluate, and manipulate intricate biological processes in vitro. These systems provide a biomimetic model for studying the intercellular interactions necessary for proper organ function and architecture in vivo. Liver organoids, formed by the self-assembly of hepatocytes, are microtissues and can exhibit specific liver characteristics for a long time in vitro. Hepatic organoids are identified as an impressive tool for evaluating potential cures and modeling liver diseases. Modeling various liver diseases, including tumors, fibrosis, non-alcoholic fatty liver, etc., allows the study of the effects of various drugs on these diseases in personalized medicine. Here, we summarize the literature relating to the hepatic stem cell microenvironment and the formation of liver Organoids.

深入了解用于疾病建模的肝脏微组织的生物制造:挑战和机遇。
在过去的十年里,高死亡率的肝病已成为世界上最重要的健康问题之一。器官移植目前被认为是治疗代偿性肝衰竭最有效的方法。越来越多的患者和捐赠者的短缺引起了重建医学方法研究人员的注意。开发对慢性肝病有效的药物的最大挑战是缺乏一个合适的临床前模型来模拟肝脏问题的微环境。类器官技术是一个快速发展的领域,使研究人员能够在体外重建、评估和操纵复杂的生物过程。这些系统为研究体内适当器官功能和结构所需的细胞间相互作用提供了仿生模型。肝类器官是由肝细胞自组装形成的,是微小的问题,可以在体外长时间表现出特定的肝脏特征。肝脏类器官被认为是评估潜在治疗方法和肝脏疾病建模的一个令人印象深刻的工具。对各种肝脏疾病进行建模,包括肿瘤、纤维化、非酒精性脂肪肝等,可以在个性化医学中研究各种药物对这些疾病的影响。在此,我们总结了有关肝干细胞微环境和肝类器官形成的文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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