The use of intranasal oxytocin in the treatment of eating disorders

IF 2.5 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Neuropeptides Pub Date : 2023-10-12 DOI:10.1016/j.npep.2023.102387

Magda Malewska-Kasprzak, Katarzyna Jowik, Marta Tyszkiewicz-Nwafor

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引用次数: 0

Abstract

Oxytocin (OXT) is a hypothalamic peptide that plays a number of roles in the body, being involved in labor and lactation, as well as cognitive-emotional processes and social behavior. In recent years, knowledge of the physiology of OXT has been repeatedly used to explore its potential role in the treatment of numerous diseases, identifying a significant role for OXT in appetite regulation, eating behavior, weight regulation, and food-related beliefs. In this review we provide an overview of publications on this topic, but due to the wealth of research, we have limited our focus to studies based on the use of intranasal OXT in psychiatric diseases, with a particular focus on the role of oxytocin in eating disorders and obesity. Accumulating evidence that OXT intranasal supplementation may provide some therapeutic benefit seems promising. In individuals with autistic spectrum disorders (ASD) and schizophrenia, OXT may affect core deficits, improving social cognition and reducing symptom severity in schizophrenia. Dysregulation of serum and CSF OXT levels, as well as polymorphisms of its genes, may affect emotion perception in patients with eating disorders and correlate with co-occurring depressive and anxiety disorders. Nevertheless, there are still many critical questions regarding the pharmacokinetics and pharmacodynamics of intranasal OXT that can only be answered in larger randomized controlled trials.

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鼻内催产素在饮食失调治疗中的应用。

催产素（OXT）是一种下丘脑肽，在体内发挥多种作用，参与分娩和哺乳，以及认知情绪过程和社会行为。近年来，OXT的生理学知识被反复用于探索其在治疗多种疾病中的潜在作用，确定了OXT在食欲调节、饮食行为、体重调节和食物相关信念中的重要作用。在这篇综述中，我们对这一主题的出版物进行了概述，但由于研究丰富，我们将重点局限于基于鼻内OXT在精神疾病中的应用的研究，特别关注催产素在饮食失调和肥胖中的作用。越来越多的证据表明，OXT鼻内补充可能提供一些治疗益处，这似乎是有希望的。在患有自闭症谱系障碍（ASD）和精神分裂症的个体中，OXT可能影响核心缺陷，改善社会认知并降低精神分裂症症状的严重程度。血清和CSF OXT水平的失调及其基因多态性可能影响饮食障碍患者的情绪感知，并与同时发生的抑郁和焦虑障碍相关。然而，关于鼻内OXT的药代动力学和药效学，仍然存在许多关键问题，这些问题只能在更大规模的随机对照试验中得到回答。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropeptides 医学-内分泌学与代谢

CiteScore

5.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.