Corpus callosum abnormalities at term-equivalent age are associated with language development at two years corrected age in infants born very preterm.

Abstract

We studied the impact of microstructural abnormalities in the corpus callosum on language development in 348 infants born very prematurely. We discovered that the fractional anisotropy of the corpus callosum anterior midbody was a significant predictor of standardized language scores at two years, independent of clinical and social risk factors.