V. Peiró-Valgañón , A. Guardiola-Arévalo , A. López Fernández , E. Llorente Herrero , M.T. Martín Fernández-Gallardo
{"title":"A multidisciplinary challenge: Therapy with phosphorus-32 for locally advanced pancreatic cancer","authors":"V. Peiró-Valgañón , A. Guardiola-Arévalo , A. López Fernández , E. Llorente Herrero , M.T. Martín Fernández-Gallardo","doi":"10.1016/j.remnie.2023.09.006","DOIUrl":null,"url":null,"abstract":"<div><p>Pancreatic cancer is a disease with a poor prognosis, and overall survival has improved the least in the last 40 years of all cancers.</p><p><span>Locally advanced pancreatic adenocarcinoma, without </span>distant metastasis<span> but with limiting vascular involvement, constitutes almost one third of these patients. This group is the focus of most research efforts to introduce treatments to increase surgical salvage rates and/or survival, with two main objectives: local control and prevention of systemic progression.</span></p><p>Intratumoural treatment with phosphorus-32 microparticles<span>, guided by echoendoscopy and combined with standard chemotherapy may have significant and clinically relevant benefits in these patients, and therefore a valuable treatment option in a disease where there is an urgent need to develop new therapies to help improve outcomes.</span></p></div>","PeriodicalId":94197,"journal":{"name":"Revista espanola de medicina nuclear e imagen molecular","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista espanola de medicina nuclear e imagen molecular","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2253808923000782","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Pancreatic cancer is a disease with a poor prognosis, and overall survival has improved the least in the last 40 years of all cancers.
Locally advanced pancreatic adenocarcinoma, without distant metastasis but with limiting vascular involvement, constitutes almost one third of these patients. This group is the focus of most research efforts to introduce treatments to increase surgical salvage rates and/or survival, with two main objectives: local control and prevention of systemic progression.
Intratumoural treatment with phosphorus-32 microparticles, guided by echoendoscopy and combined with standard chemotherapy may have significant and clinically relevant benefits in these patients, and therefore a valuable treatment option in a disease where there is an urgent need to develop new therapies to help improve outcomes.
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