Single nucleotide polymorphisms in inducible nitric oxide synthase gene are not associated with persistent apical periodontitis

IF 1.3 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Australian Endodontic Journal Pub Date : 2023-09-19 DOI:10.1111/aej.12796

Sandra Regina Santos Meyfarth DDS, MSc, Lívia Azeredo Alves Antunes DDS, MSc, PhD, Jhenyfer da Silva Tavares BSc, Ludmila da Silva Guimarães DDS, MSc, PhD, Erlange Andrade Borges da Silva DDS, MSc, PhD, Flares Baratto-Filho DDS, MSc, PhD, Erika Calvano Küchler DDS, MSc, PhD, Alice Corrêa Silva-Sousa DDS, MSc, PhD, Manoel Damião Sousa-Neto DDS, MSc, PhD, Leonardo Santos Antunes DDS, MSc, PhD

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引用次数: 0

Abstract

The aim of this study was to investigate whether there is an association between inducible in single nucleotide polymorphisms in nitric oxide synthase (rs2297518 and rs2779249) and persistent apical periodontitis. A total of 291 Brazilian subjects were included: 125 with signs/symptoms of persistent apical periodontitis and 166 with root canal-treated teeth exhibiting healthy perirradicular tissues. Endodontically treated patients were followed up after 1 year. The two single nucleotide polymorphisms in nitric oxide synthase were analysed using real-time polymerase chain reaction. Chi-square test and odds ratio with 95% confidence intervals were performed to compare genotype distributions between ‘healed’ and ‘persistent apical periodontitis’ groups (p < 0.05). Logistic regression analysis was used to evaluate SNP–SNP interactions. The allele and genotype distributions for the polymorphisms between the persistent apical periodontitis and healed groups were not statistically significant (p > 0.05). In the logistic regression analysis, the polymorphisms were not associated with persistent apical periodontitis and SNP–SNP interactions.

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诱导型一氧化氮合酶基因单核苷酸多态性与持续性根尖周炎无关。

本研究的目的是调查一氧化氮合酶（rs2297518和rs2779249）中可诱导的单核苷酸多态性与持续性根尖周炎之间是否存在关联。共纳入291名巴西受试者：125名有持续性根尖周炎的体征/症状，166名有根管治疗的牙齿显示出健康的眶周组织。接受牙髓治疗的患者在1 年利用实时聚合酶链式反应分析了一氧化氮合酶的两个单核苷酸多态性。卡方检验和95%置信区间的比值比用于比较“治愈”和“持续性根尖周炎”组之间的基因型分布（p 0.05）。在逻辑回归分析中，多态性与持续性根尖周炎和SNP-SNP相互作用无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Australian Endodontic Journal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.50

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： The Australian Endodontic Journal provides a forum for communication in the different fields that encompass endodontics for all specialists and dentists with an interest in the morphology, physiology, and pathology of the human tooth, in particular the dental pulp, root and peri-radicular tissues. The Journal features regular clinical updates, research reports and case reports from authors worldwide, and also publishes meeting abstracts, society news and historical endodontic glimpses. The Australian Endodontic Journal is a publication for dentists in general and specialist practice devoted solely to endodontics. It aims to promote communication in the different fields that encompass endodontics for those dentists who have a special interest in endodontics.