Teratogenic impacts of Antiepileptic drugs on development, behavior and reproduction in Drosophila melanogaster

IF 2.6 3区医学 Q3 NEUROSCIENCES

Neurotoxicology and teratology Pub Date : 2023-10-05 DOI:10.1016/j.ntt.2023.107305

Shamapari R., Nagaraj K.

引用次数: 0

Abstract

Clobazam (CLB) and Vigabatrin (VGB) are the two widely used Antiepileptic drugs, which may have teratogenic potentiality and it has been evaluated in the fruit fly Drosophila melanogaster. These different concentrations of CLB (0.156, 0.25, and 0.312 μg/ml) and VGB (17.6, 22, and 44 μg/ml) were used to evaluate the life–history parameters, developmental, and behavioral abnormalities. The results revealed that life-history parameters (fecundity, fertility, larval and pupal mortality) were significantly affected along with varied developmental duration, and pupal and adult deformities in flies on exposure of CLB and VGB in concentration dependent manner. The present study demonstrated that the prenatal treatment of CLB and VGB has displayed clear teratogenic potentiality with various deformities in the fruit fly. The findings could be correlated with the various abnormalities in human caused by the use of AEDs.

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抗癫痫药物对黑腹果蝇发育、行为和繁殖的致畸影响。

Clobazam（CLB）和Vigabatrin（VGB）是两种应用广泛的抗癫痫药物，可能具有致畸潜力，已在果蝇中进行了评价。这些不同浓度的CLB（0.156、0.25和0.312 μg/ml）和VGB（17.6、22和44 μg/ml）用于评估生活史参数、发育和行为异常。结果表明，暴露于CLB和VGB的苍蝇的生活史参数（繁殖力、生育能力、幼虫和蛹死亡率）随着发育时间的变化而受到显著影响，蛹和成虫畸形呈浓度依赖性。本研究表明，CLB和VGB的产前治疗对果蝇的各种畸形表现出明显的致畸潜力。这些发现可能与使用AED引起的人类各种异常有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurotoxicology and teratology 医学-毒理学

CiteScore

5.60

自引率

10.30%

发文量

审稿时长

58 days

期刊介绍： Neurotoxicology and Teratology provides a forum for publishing new information regarding the effects of chemical and physical agents on the developing, adult or aging nervous system. In this context, the fields of neurotoxicology and teratology include studies of agent-induced alterations of nervous system function, with a focus on behavioral outcomes and their underlying physiological and neurochemical mechanisms. The Journal publishes original, peer-reviewed Research Reports of experimental, clinical, and epidemiological studies that address the neurotoxicity and/or functional teratology of pesticides, solvents, heavy metals, nanomaterials, organometals, industrial compounds, mixtures, drugs of abuse, pharmaceuticals, animal and plant toxins, atmospheric reaction products, and physical agents such as radiation and noise. These reports include traditional mammalian neurotoxicology experiments, human studies, studies using non-mammalian animal models, and mechanistic studies in vivo or in vitro. Special Issues, Reviews, Commentaries, Meeting Reports, and Symposium Papers provide timely updates on areas that have reached a critical point of synthesis, on aspects of a scientific field undergoing rapid change, or on areas that present special methodological or interpretive problems. Theoretical Articles address concepts and potential mechanisms underlying actions of agents of interest in the nervous system. The Journal also publishes Brief Communications that concisely describe a new method, technique, apparatus, or experimental result.