Association between platelet lymphocyte ratio and neutrophil lymphocyte ratio and clinical outcomes following carotid endarterectomy.

IF 0.8 Q4 PERIPHERAL VASCULAR DISEASE

Jornal Vascular Brasileiro Pub Date : 2023-08-28 eCollection Date: 2023-01-01 DOI:10.1590/1677-5449.202201222

Vinicius Adorno Gonçalves, Martin Andreas Geiger, Danilo Augusto Sarti, Ana Terezinha Guillaumon

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引用次数: 0

Abstract

Background: Approximately 30% of stroke cases result from carotid disease. Although several risk factors for complications after carotid endarterectomy have been identified, the existence of a biomarker that can estimate postoperative risk in these patients has not yet been proven.

Objectives: This study aimed to investigate correlations between the platelet-lymphocyte ratio (PLR) and the neutrophil-lymphocyte ratio (NLR) and postoperative clinical outcomes in patients undergoing carotid endarterectomy.

Methods: A retrospective study was conducted, including 374 patients who underwent carotid endarterectomy between 2002 and 2019 due to moderate to high extracranial internal carotid artery stenosis. Their platelet-lymphocyte ratio and neutrophil-lymphocyte ratios were obtained from the same blood samples.

Results: There was a statistically significant correlation between the PLR and the occurrence of restenosis (p < 0.01) and acute myocardial infarction (AMI) after endarterectomy (p = 0.03). Additionally, there was a statistically significant correlation between the PLR and the combined outcomes stroke and/or AMI and/or death (p = 0.03) and stroke and/or AMI and/or death and/or restenosis (p < 0.01). However, there were no significant correlations between NLR and these outcomes (p = 0.05, p = 0.16).

Conclusions: The platelet-lymphocyte ratio proved to be a useful test for predicting occurrence of strokes, acute myocardial infarctions, and deaths during the postoperative period after carotid endarterectomy. It was also associated with the risk of postoperative restenosis.

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颈动脉内膜切除术后血小板-淋巴细胞比率和中性粒细胞-淋巴细胞比率与临床结果的关系。

背景：大约30%的中风病例是由颈动脉疾病引起的。尽管颈动脉内膜切除术后并发症的几个风险因素已经确定，但尚未证明存在可以估计这些患者术后风险的生物标志物。目的：本研究旨在探讨颈动脉内膜切除术患者血小板淋巴细胞比率（PLR）和中性粒细胞淋巴细胞比率（NLR）与术后临床结果之间的相关性。方法：进行回顾性研究，包括2002年至2019年间因中度至高度颅外颈内动脉狭窄而接受颈动脉内膜切除术的374名患者。他们的血小板-淋巴细胞比率和中性粒细胞-淋巴细胞比率是从相同的血液样本中获得的。结果：PLR与动脉内膜切除术后再狭窄（p<0.01）和急性心肌梗死（AMI）的发生率（p=0.03）有显著相关性，PLR与卒中和/或AMI和/或死亡（p=0.03）、卒中和//或AMI、/或死亡和/或再狭窄（p<0.01）的综合转归之间存在统计学显著相关性，NLR与这些结果之间没有显著相关性（p=0.05，p=0.16）。结论：血小板-淋巴细胞比率被证明是预测颈动脉内膜切除术后卒中、急性心肌梗死和死亡的有用测试。它还与术后再狭窄的风险有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jornal Vascular Brasileiro Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The Jornal Vascular Brasileiro is editated and published quaterly to select and disseminate high-quality scientific contents concerning original research, novel surgical and diagnostic techniques, and clinical observations in the field of vascular surgery, angiology, and endovascular surgery. Its abbreviated title is J. Vasc. Bras., which should be used in bibliographies, footnotes and bibliographical references and strips.