Prognostic Value of the Average Lung CT Number in Patients with Acute Paraquat Poisoning.

IF 1.2 4区 医学 Q3 EMERGENCY MEDICINE
Emergency Medicine International Pub Date : 2023-09-12 eCollection Date: 2023-01-01 DOI:10.1155/2023/4443680
Xinrui Jiang, Hengjun Liu, Geng Lu, Jiawei Zhou, Jun Wang, Binxia Shao, Peng Xu
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引用次数: 0

Abstract

Objective: The chest computed tomography (CT) examination is an important clinical examination in the diagnosis and monitoring of paraquat- (PQ-) induced lung injury. The aim of this study was to explore the prognostic value of the average lung CT number acquired by quantitative CT techniques in patients with acute paraquat poisoning in the early stages of the disease.

Methods: 46 patients who suffered from acute PQ poisoning in the emergency department of the Nanjing Drum Tower Hospital from January 2015 to June 2020 were enrolled in the present study. The patients were divided into survival group (n = 21) and nonsurvival group (n = 25). Clinical data were collected from subjects who met the inclusion criteria, including general information, personal disease history, and laboratory test indicators. The average lung CT numbers of each patient were obtained by quantitative CT techniques. Receiver operating characteristic (ROC) analysis was conducted to assess the prognostic value of average lung CT number in patients with acute paraquat poisoning.

Results: The average CT numbers of the middle-lung, lower-lung, and whole lung fields in the nonsurvival group were significantly higher than those of the survival group (p < 0.0001). However, the upper-lung field was not significantly different between the two groups (p = 0.7765). The AUCs of different levels ranged from 0.554 to 0.977, among which the lower-lung field presented the largest AUC of 0.977 (95% CI: 0.943∼1; cut-off value: -702Hu; sensitivity 96%; specificity, 90.5%; YI: 0.865), followed by the whole lung field 0.914 (95% CI: 0.830∼0.999; cut-off value: -727Hu; sensitivity 76%; specificity, 95.2%; YI: 0.712) and the middle-lung field 0.87 (95% CI: 0.768∼0.971; cut-off value: -779Hu; sensitivity 80%; specificity, 85.7%; YI: 0.657).

Conclusion: The present study indicated that the average lung CT number could be used to evaluate the relationship between the severity of PQ-induced lung injury and prognosis, especially in the lower-lung field. However, further research is needed to draw a clear conclusion.

Abstract Image

Abstract Image

Abstract Image

急性百草枯中毒患者肺部CT平均值的预后价值。
目的:胸部计算机断层扫描(CT)检查是诊断和监测百草枯(PQ-)所致肺损伤的一项重要临床检查。本研究的目的是探讨定量CT技术获得的平均肺部CT数对急性百草枯中毒早期患者的预后价值。方法:对2015年1月至2020年6月在南京鼓楼医院急诊科就诊的46例急性PQ中毒患者进行研究。将患者分为存活组(n = 21)和非存活组(n = 25)。临床数据来自符合纳入标准的受试者,包括一般信息、个人病史和实验室测试指标。通过定量CT技术获得每个患者的平均肺部CT数量。进行受试者操作特征(ROC)分析,以评估急性百草枯中毒患者平均肺部CT数的预后价值。结果:非存活组的中肺、下肺和全肺野的平均CT数显著高于存活组(p<0.0001)。但上肺野在两组之间没有显著差异(p=0.7765)。不同水平的AUCs在0.554至0.977之间,其中下肺野的AUC最大,为0.977(95%CI:0.943~1;截止值:-702Hu;敏感性96%;特异性90.5%;YI:0.865),其次是全肺野0.914(95%CI:0.830~0.999;临界值:-727Hu;敏感性76%;特异性95.2%;YI:0.712)和中肺野0.87(95%CI:0.768~0.971;临界值779Hu;灵敏度80%;特异性85.7%;YI:0.657)PQ引起的肺损伤和预后,尤其是在下肺野。然而,还需要进一步的研究才能得出明确的结论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Emergency Medicine International
Emergency Medicine International EMERGENCY MEDICINE-
CiteScore
0.10
自引率
0.00%
发文量
187
审稿时长
17 weeks
期刊介绍: Emergency Medicine International is a peer-reviewed, Open Access journal that provides a forum for doctors, nurses, paramedics and ambulance staff. The journal publishes original research articles, review articles, and clinical studies related to prehospital care, disaster preparedness and response, acute medical and paediatric emergencies, critical care, sports medicine, wound care, and toxicology.
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