Microbial-host isozyme: A novel target in "drug the bug" strategies for diabetes.

Guojun Wu, Naisi Zhao, Liping Zhao
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Abstract

The role of the gut microbiome in metabolic diseases, such as diabetes, has emerged as a pivotal area of medical research. Wang et al.'s recent work reported that a gut bacteria-derived microbial-host isozyme, mimicking a human enzyme responsible for blood glucose regulation, can significantly impact the efficacy of diabetes medications.

微生物宿主同工酶:糖尿病“药虫”策略中的一个新靶点。
肠道微生物组在糖尿病等代谢性疾病中的作用已成为医学研究的一个关键领域。王等人最近的研究表明,肠道细菌衍生的微生物宿主同工酶,模仿负责血糖调节的人类酶,可以显著影响糖尿病药物的疗效。
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