Pioneer factors — key regulators of chromatin and gene expression

IF 39.1 1区生物学 Q1 GENETICS & HEREDITY

Nature Reviews Genetics Pub Date : 2023-09-22 DOI:10.1038/s41576-023-00648-z

Martha L. Bulyk, Jacques Drouin, Melissa M. Harrison, Jussi Taipale, Kenneth S. Zaret

引用次数: 0

Abstract

Pioneer factors are a group of transcription factors with important roles in gene regulation during development. Their unique ability to bind to compacted chromatin, promoting its remodelling for gene expression, sets them apart from other regulatory proteins and makes them essential players in cellular differentiation, fate determination and reprogramming. Here, we have tasked five experts with discussing our current understanding of pioneer factors and their functions to showcase why exploring these proteins offers unique insights into gene regulation and cellular identity. Five leading researchers provide their perspectives on our current understanding of pioneer factors and their important gene regulatory roles in cell differentiation, cell fate determination and reprogramming.

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先锋因子-染色质和基因表达的关键调节因子。

先锋因子是一组转录因子，在发育过程中对基因调控起着重要作用。先锋因子具有独特的能力，能与压实的染色质结合，促进染色质重塑，从而促进基因表达，这使它们有别于其他调控蛋白，并使它们成为细胞分化、命运决定和重编程过程中的重要角色。在这里，我们委托五位专家讨论我们目前对先驱因子及其功能的理解，以说明为什么探索这些蛋白能为基因调控和细胞特性提供独特的见解。五位顶尖研究人员就我们目前对先驱因子及其在细胞分化、细胞命运决定和重编程中的重要基因调控作用的理解发表了自己的观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Genetics 生物-遗传学

CiteScore

57.40

自引率

0.50%

发文量

113

审稿时长

6-12 weeks

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