Natural products as a source of new anticancer chemotypes.

IF 5.4 2区医学 Q1 CHEMISTRY, MEDICINAL

Expert Opinion on Therapeutic Patents Pub Date : 2023-11-01 Epub Date: 2024-01-11 DOI:10.1080/13543776.2023.2265561

Francesco Melfi, Simone Carradori, Noemi Mencarelli, Cristina Campestre, Marialucia Gallorini, Silvia Di Giacomo, Antonella Di Sotto

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引用次数: 0

Abstract

Introduction: Exploring the chemical diversity and molecular mechanisms of natural products continues to be an important research area for identifying novel promising therapeutic approaches for fighting cancer. This is a complex disease and poses important challenges, which require not only targeted interventions to improve chemotherapy efficacy and tolerability, but also adjuvant strategies to counteract chemoresistance development and relapses.

Areas covered: After a brief description of the recent literature on the anticancer potential of natural compounds, we searched for patents following the PRISMA guidelines, filtering the results published from 2019 onwards. In addition, some relevant publications from the overall scientific literature were also discussed.

Expert opinion: This review comprehensively covers and analyzes the most recent advances on the anticancer mechanism of licensed natural compounds and their chemical optimization. Patentability of natural compounds was discussed according to the recent legislation in the U.S.A. and Europe.

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天然产物作为新的抗癌化学型的来源。

简介：探索天然产物的化学多样性和分子机制仍然是确定新的有前景的治疗癌症方法的重要研究领域。癌症是一种复杂的疾病，面临着重要的挑战，不仅需要有针对性的干预措施来提高化疗疗效和耐受性，还需要辅助策略来对抗化疗耐药性的发展和复发。涵盖的领域：在简要描述了最近关于天然化合物抗癌潜力的文献后，我们根据PRISMA指南搜索专利，过滤了2019年以后发表的结果。此外，还对一些相关出版物的整体科学文献进行了讨论。专家意见：这篇综述全面涵盖并分析了许可天然化合物抗癌机制及其化学优化的最新进展。根据美国和欧洲最近的立法讨论了天然化合物的专利权。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Opinion on Therapeutic Patents 医学-药学

CiteScore

12.10

自引率

1.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Expert Opinion on Therapeutic Patents (ISSN 1354-3776 [print], 1744-7674 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on recent pharmaceutical patent claims, providing expert opinion the scope for future development, in the context of the scientific literature. The Editors welcome: Reviews covering recent patent claims on compounds or applications with therapeutic potential, including biotherapeutics and small-molecule agents with specific molecular targets; and patenting trends in a particular therapeutic area Patent Evaluations examining the aims and chemical and biological claims of individual patents Perspectives on issues relating to intellectual property The audience consists of scientists, managers and decision-makers in the pharmaceutical industry and others closely involved in R&D Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days.