Prospective validation of an equation based on plasma cystatin C for monitoring the glomerular filtration rate in children treated with cisplatin or ifosfamide for cancer.

IF 2.7 4区医学 Q3 ONCOLOGY

Cancer Chemotherapy and Pharmacology Pub Date : 2024-04-01 Epub Date: 2023-10-03 DOI:10.1007/s00280-023-04597-6

Marie Lambert, Mathieu Alonso, Caroline Munzer, Marie-Christine Zimoch, Laurence Malard, Marion Gambart, Marie-Pierre Castex, Carla Martins, Marlène Pasquet, Etienne Chatelut

引用次数: 0

Abstract

We recently proposed an equation to estimate the glomerular filtration rate (GFR) in children with cancer based on plasma cystatin C and serum creatinine levels together with body weight (the "CysPed equation"). The current clinical study reports a prospective evaluation of this equation in 18 children treated by nephrotoxic chemotherapy. The CysPed equation resulted in less bias and greater precision compared to two equations previously proposed equations by Schwartz, with or without plasma cystatin C. Moreover, the decrease in GFR due to chemotherapy was clearly identified by the CysPed equation. This equation may be used to monitor the renal function in childhood cancer units.

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基于血浆胱抑素C的方程用于监测癌症顺铂或异烟酰胺治疗儿童肾小球滤过率的前瞻性验证。

我们最近提出了一个方程，根据血浆胱抑素C和血清肌酸酐水平以及体重来估计癌症儿童的肾小球滤过率（GFR）（“CysPed方程”）。目前的临床研究报告了对18名接受肾毒性化疗的儿童的这一等式的前瞻性评估。CysPed方程与Schwartz先前提出的两个方程相比，在有或没有血浆胱抑素C的情况下，偏差更小，精度更高。此外，CysPed方程式清楚地表明了化疗导致的GFR降低。该方程可用于监测儿童癌症单位的肾功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Chemotherapy and Pharmacology 医学-药学

CiteScore

6.10

自引率

3.30%

发文量

116

审稿时长

2.5 months

期刊介绍： Addressing a wide range of pharmacologic and oncologic concerns on both experimental and clinical levels, Cancer Chemotherapy and Pharmacology is an eminent journal in the field. The primary focus in this rapid publication medium is on new anticancer agents, their experimental screening, preclinical toxicology and pharmacology, single and combined drug administration modalities, and clinical phase I, II and III trials. It is essential reading for pharmacologists and oncologists giving results recorded in the following areas: clinical toxicology, pharmacokinetics, pharmacodynamics, drug interactions, and indications for chemotherapy in cancer treatment strategy.