The roles of intracellular proteolysis in cardiac ischemia-reperfusion injury.

IF 7.5 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Bridgette Hartley, Wesam Bassiouni, Richard Schulz, Olivier Julien
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引用次数: 0

Abstract

Ischemic heart disease remains a leading cause of human mortality worldwide. One form of ischemic heart disease is ischemia-reperfusion injury caused by the reintroduction of blood supply to ischemic cardiac muscle. The short and long-term damage that occurs due to ischemia-reperfusion injury is partly due to the proteolysis of diverse protein substrates inside and outside of cardiomyocytes. Ischemia-reperfusion activates several diverse intracellular proteases, including, but not limited to, matrix metalloproteinases, calpains, cathepsins, and caspases. This review will focus on the biological roles, intracellular localization, proteolytic targets, and inhibitors of these proteases in cardiomyocytes following ischemia-reperfusion injury. Recognition of the intracellular function of each of these proteases includes defining their activation, proteolytic targets, and their inhibitors during myocardial ischemia-reperfusion injury. This review is a step toward a better understanding of protease activation and involvement in ischemic heart disease and developing new therapeutic strategies for its treatment.

Abstract Image

细胞内蛋白水解在心脏缺血再灌注损伤中的作用。
缺血性心脏病仍然是全世界人类死亡的主要原因。缺血性心脏病的一种形式是由缺血心肌重新引入血液供应引起的缺血再灌注损伤。缺血再灌注损伤引起的短期和长期损伤部分是由于心肌细胞内外不同蛋白质底物的蛋白水解。缺血再灌注激活几种不同的细胞内蛋白酶,包括但不限于基质金属蛋白酶、钙蛋白酶、组织蛋白酶和半胱天冬酶。这篇综述将集中于心肌缺血再灌注损伤后这些蛋白酶的生物学作用、细胞内定位、蛋白水解靶点和抑制剂。对这些蛋白酶中每一种的细胞内功能的识别包括确定它们在心肌缺血再灌注损伤过程中的激活、蛋白水解靶点及其抑制剂。这篇综述是朝着更好地了解蛋白酶激活和参与缺血性心脏病以及开发新的治疗策略迈出的一步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Basic Research in Cardiology
Basic Research in Cardiology 医学-心血管系统
CiteScore
16.30
自引率
5.30%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Basic Research in Cardiology is an international journal for cardiovascular research. It provides a forum for original and review articles related to experimental cardiology that meet its stringent scientific standards. Basic Research in Cardiology regularly receives articles from the fields of - Molecular and Cellular Biology - Biochemistry - Biophysics - Pharmacology - Physiology and Pathology - Clinical Cardiology
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