Fas ligand intracellular signaling: does PSTPIP mediate T cell death?

IF 6.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Apoptosis Pub Date : 2023-10-04 DOI:10.1007/s10495-023-01892-8

Rafael Cardoso Maciel Costa Silva

引用次数: 0

Abstract

Fas and Fas ligand (FasL)-induced cell death is critical for the appropriate regulation of immune responses, especially those mediated by T cells. In this letter, several studies are discussed that reinforce the importance of FasL intracellular signaling for CD4 + T cell death, which might involve PSTPIP phosphatase and/or MAPKs.

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Fas配体细胞内信号传导：PSTPIP介导T细胞死亡吗？

Fas和Fas配体（FasL）诱导的细胞死亡对于适当调节免疫反应，尤其是T细胞介导的免疫反应至关重要。在这封信中，讨论了几项研究，这些研究加强了FasL细胞内信号传导对CD4的重要性 + T细胞死亡，可能涉及PSTPIP磷酸酶和/或MAPKs。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Apoptosis 生物-生化与分子生物学

CiteScore

9.10

自引率

4.20%

发文量

审稿时长

1 months

期刊介绍： Apoptosis, a monthly international peer-reviewed journal, focuses on the rapid publication of innovative investigations into programmed cell death. The journal aims to stimulate research on the mechanisms and role of apoptosis in various human diseases, such as cancer, autoimmune disease, viral infection, AIDS, cardiovascular disease, neurodegenerative disorders, osteoporosis, and aging. The Editor-In-Chief acknowledges the importance of advancing clinical therapies for apoptosis-related diseases. Apoptosis considers Original Articles, Reviews, Short Communications, Letters to the Editor, and Book Reviews for publication.