Adrenal limb thickness is associated with metabolism profiles in patients with diabetes: A cross-sectional study

IF 3 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Pub Date : 2023-09-26 DOI:10.1111/1753-0407.13479

Yingning Liu, Xiantong Zou, Wei Zhao, Xun Yao, Lexuan Wang, LingLi Zhou, Rui Zhang, Yingying Luo, Meng Li, Xiuying Zhang, Yu Zhu, Xiaoling Cai, Xianghai Zhou, Xueyao Han, Linong Ji

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Abstract

Background

The association between adrenal size and metabolic profiles in patients with diabetes mellitus (DM) is unclear. This study was conducted to determine whether the adrenal thickness measured by computed tomography (CT) is correlated with the metabolic profiles of patients with DM.

Methods

This was a cross-sectional study including 588 Chinese hospitalized patients with DM without comorbidities or medications known to affect adrenal morphology or hormone secretion. Adrenal limb thickness was measured on unenhanced chest CT. Participants were stratified into tertiles according to their total adrenal limb thickness. Linear and logistic regression models were used to estimate the correlations.

Results

After adjustment for sex and age, the adrenal thickness was positively associated with body mass index (BMI), waist circumference (WC), urinary albumin/creatinine ratio, and 24-h urinary free cortisol (UFC) and negatively correlated with high-density lipoprotein cholesterol. The sequential equation model (SEM) suggested UFC partially mediated the effect of adrenal limb thickness on WC by 12%. Adrenal thickness, but not UFC, was associated with a higher risk of existing hypertension (odds ratio [OR] = 3.78, 95% confidence interval [CI] 1.58, 9.02) and hyperlipidemia (OR = 2.76, 95% CI 1.03, 7.38), independent of age, gender, BMI, and WC.

Conclusions

The adrenal thickness is independently associated with BMI, WC, cortisol levels, urinary albumin/creatinine ratio, hypertension, and dyslipidemia but not glycemic parameters in patients with diabetes. Our study encourages further studies to investigate the role of adrenal physiology in patients with diabetes.

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糖尿病患者肾上腺肢体厚度与代谢特征相关：一项横断面研究。

背景：糖尿病患者肾上腺大小与代谢特征之间的关系尚不清楚。本研究旨在确定计算机断层扫描（CT）测量的肾上腺厚度是否与糖尿病患者的代谢特征相关。方法：这是一项横断面研究，包括588名中国住院的糖尿病患者，他们没有合并症或已知会影响肾上腺形态或激素分泌的药物。在未增强的胸部CT上测量肾上腺肢体厚度。根据参与者的肾上腺肢体总厚度将其分为三层。使用线性和逻辑回归模型来估计相关性。结果：校正性别和年龄后，肾上腺厚度与体重指数（BMI）、腰围（WC）、尿白蛋白/肌酐比值和24小时尿游离皮质醇（UFC）呈正相关，与高密度脂蛋白胆固醇呈负相关。序列方程模型（SEM）表明UFC部分介导了肾上腺肢体厚度对WC的影响12%。肾上腺厚度（而非UFC）与高血压的高风险相关（比值比[OR] = 3.78,95%置信区间[CI]1.58,9.02）和高脂血症（OR = 2.76，95%CI 1.03,7.38），与年龄、性别、BMI和WC无关。结论：糖尿病患者的肾上腺厚度与BMI、WC、皮质醇水平、尿白蛋白/肌酐比值、高血压和血脂异常独立相关，但与血糖参数无关。我们的研究鼓励进一步研究肾上腺生理学在糖尿病患者中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.