Tumor-microenvironment responsive nano-carrier system for therapy of prostate cancer

IF 4.2 3区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of Materials Science: Materials in Medicine Pub Date : 2023-09-21 DOI:10.1007/s10856-023-06749-9

Lujing Li, Renjie Li, Jiachun Li, Jiyi Yao, Qingyuan Zhang, Qiao Ji, Zuofeng Xu

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引用次数: 0

Abstract

Poor selectivity, low bioavailability and serious systemic side-effects have limited the application of traditional chemotherapy method for treatment of prostate cancer. Stimuli-responsive drug delivery systems for chemotherapy are mainly based on the unique characteristics of tumor microenvironment. In this study, the GSH-sensitive poly-TTG-SS@DTX NPs (DTX-loaded poly-Tetraethylene glycol nanoparticles) were designed and synthesized, which were characterized with nanosized diameter (92.8 ± 2.5 nm) and negatively charged surface charge (−24.7 ± 5.56 mV). Experiments in vitro showed that poly-TTG-SS@DTX NPs had good compatibility to healthy cells and strong anti-tumor effect because of rapid and sustained drug release of DTX from poly-TTG-SS@DTX NPs under the tumor-microenvironment condition. The cellular activity remained greater than 90% when the concentration of poly-TTG-SS NPs reached as high as 100 µg/mL treated on healthy cells. The killing effect of DTX loading NPs group on C4-2 cells was stronger than that of free anti-tumor drug and free DTX combined with the blank nano-carrier (25.21% vs 19.93% vs 20.96%). In conclusion, poly-TTG-SS@DTX NPs may provide a new therapeutic strategy for the chemotherapy of prostate cancer.

Graphical Abstract

Abstract Image

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肿瘤微环境响应性纳米载体系统治疗前列腺癌症

选择性差、生物利用度低、全身副作用严重，限制了传统化疗方法在癌症治疗中的应用。用于化疗的刺激反应性药物递送系统主要基于肿瘤微环境的独特特性。在本研究中，GSH敏感性poly-TTG-SS@DTX设计并合成了纳米颗粒（DTX负载的聚四乙二醇纳米颗粒），其具有纳米直径（92.8 ± 2.5 nm）和带负电的表面电荷（−24.7 ± 5.56 mV）。体外实验表明poly-TTG-SS@DTXNPs与健康细胞具有良好的相容性，并且由于DTX从poly-TTG-SS@DTX肿瘤微环境条件下的NPs。当聚TTG-SS NP的浓度高达100时，细胞活性保持大于90% µg/mL在健康细胞上处理。负载DTX的NPs组对C4-2细胞的杀伤作用强于游离抗肿瘤药物和游离DTX与空白纳米载体的联合杀伤作用（25.21%vs19.93%vs20.96%），poly-TTG-SS@DTXNP可能为癌症的化疗提供一种新的治疗策略。图形摘要

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来源期刊

Journal of Materials Science: Materials in Medicine 工程技术-材料科学：生物材料

CiteScore

8.00

自引率

0.00%

发文量

审稿时长

3.5 months

期刊介绍： The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.