[Observation of Nutritional Status Changes in Patients with Acute Leukemia During Chemotherapy].

Li-Ling Zong, Jing Yang, Sheng-Li Xue, De-Pei Wu, Xia-Ming Zhu, Yong-Qin Ge, Qiao-Cheng Qiu
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引用次数: 0

Abstract

Objective: To assess changes of nutritional status by comprehensive nutrition assessment including nutritional risk screening, dietary assessment, blood biochemical index, and body composition in acute leukemia patients who had undergone chemotherapy.

Methods: A total of 169 patients with acute leukemia treated at The First Affiliated Hospital of Soochow University from June 2018 to August 2019 were recruited for this study. Before and after chemotherapy, the NRS-2002 and PG-SGA scales, dietary intake, blood biochemical index and body composition were evaluated to compare the changes of nutritional status.

Results: NRS-2002 score and PG-SGA score after chemotherapy were significantly increased than those before chemotherapy (P<0.001). Many patients had insufficient nutritional intake during chemotherapy, and the dietary intake score of patients with induction chemotherapy was significantly lower than that of patients with consolidation chemotherapy (P=0.043). The results of multivariate analysis showed that induction chemotherapy was the independent risk factor for the increase of PG-SGA scores and the decrease of dietary intake (all P<0.05). After chemotherapy, the white blood cell count, hemoglobin, and platelet count were significantly decreased (P<0.001), the prealbumin was significantly increased (P<0.001), and the blood glucose was increased (P=0.04), but albumin was not significantly changed. The weight, body mass index, fat-free mass, skeletal muscle mass and intracellular water were all significantly decreased (P<0.001), and visceral fat area was increased significantly after chemotherapy (P<0.05), especially in newly-diagnosed acute lymphoblastic leukemia patients after the induction of chemotherapy.

Conclusion: The nutritional status of patients with acute leukemia has undergone significant changes after chemotherapy. A single indicator has limited significance for nutritional status assessment. Comprehensive assessment of nutritional status by multiple tools is worthy of clinical application.

急性白血病患者化疗期间营养状况变化的观察
目的:通过营养风险筛查、膳食评价、血液生化指标、体成分等综合营养评价,评价急性白血病化疗患者营养状况的变化。方法:选取2018年6月至2019年8月在苏州大学第一附属医院接受治疗的169例急性白血病患者为研究对象。化疗前后分别评价NRS-2002、PG-SGA量表、膳食摄入量、血液生化指标、体成分,比较营养状况的变化。结果:化疗后患者NRS-2002评分、PG-SGA评分均较化疗前显著升高(p结论:急性白血病患者化疗后营养状况发生显著变化。单一指标对营养状况评估的意义有限。多种工具综合评价营养状况,值得临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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