A purinergic call to arms from dying brown adipocytes.

IF 4.1 Q2 CELL BIOLOGY

Cell Stress Pub Date : 2022-07-25 eCollection Date: 2022-07-01 DOI:10.15698/cst2022.07.269

Mohammed K Hankir

引用次数: 0

Abstract

Brown adipocytes react to temperature and nutritional challenges by ramping up their metabolism and generating heat. This adaptation to changes in the environment is crucial for defending organismal homeostasis, but is impaired in obesity and during aging. Writing in Nature, Niemann et al. show that brown adipocytes become apoptotic under thermoneutral conditions and release ATP, which in turn is converted extracellularly into inosine. They further present evidence that pharmacological and genetic manipulations that enhance signalling of this purine metabolite stimulates thermogenesis in brown adipocytes and promotes metabolic health.

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垂死的棕色脂肪细胞发出的嘌呤能召唤。

棕色脂肪细胞通过加速新陈代谢和产生热量来应对温度和营养挑战。这种对环境变化的适应对于维护机体内稳态至关重要，但在肥胖和衰老过程中受到损害。Niemann等人在Nature上发表的文章表明，棕色脂肪细胞在热中性条件下发生凋亡，并释放ATP，而ATP又在细胞外转化为肌苷。他们进一步提出的证据表明，药理学和遗传学操作可以增强这种嘌呤代谢物的信号传导，刺激棕色脂肪细胞的产热，促进代谢健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

13.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.