Intrahepatic cholestasis of pregnancy can increase the risk of metabolic disorders: A meta-analysis.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2022-10-15 DOI:10.5937/jomb0-33222

Leiying Zhang, Chen Tang, Chenlian Ye, Luren Huang, Yan Wu

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引用次数: 1

Abstract

Background: Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common complications during pregnancy. Studies indicated that abnormal bile acid metabolism is related to its pathogenesis. Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-specific liver disease, which classic symptoms include generalized pruritus that commonly and biochemical evidence of elevated bile acids. Our study aimed to explore the correlation between the ICP presence and risk of GDM, PE incident in pregnant women.

Methods: A meta-analysis, which included 10 eligible studies including 17,688 ICP cases and 1,386,771 controls, was performed to assess the correlation of ICP with preeclampsia (PE) and gestational diabetes mellitus (GDM). There were 7 studies investigating the relationship between ICP and PE, and 9 studies that evaluated the relationship between ICP and GDM. All eligible studies were screened from Pubmed, Web of Science and EBSCO databases.

Results: The results of this meta-analysis indicate that ICP significantly increase the risk for both PE (pooled odds ratio OR: 2.56 95%CI: 2.27 2.88, I2 heterogeneity = 35%, p heterogeneity = 0.16) and GDM (pooled OR: 2.28 95%CI: 1.69 3.07, I2 heterogeneity = 81%, p heterogeneity < 0.001). In the sensitivity analysis of GDM, excluding the largest heterogeneity study cannot change the result (pooled OR: 2.86 95%CI: 2.59 3.16, I2 heterogeneity = 0%, p heterogeneity = 0.56).

Conclusions: This meta-analysis shows that ICP is closely associated with ICP increased risk of PE and GDM) during pregnancy.

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妊娠肝内胆汁淤积可增加代谢紊乱的风险:一项荟萃分析。

背景:妊娠期糖尿病(GDM)和先兆子痫(PE)是妊娠期常见的并发症。研究表明，胆汁酸代谢异常与其发病机制有关。妊娠期肝内胆汁淤积症(ICP)是最常见的妊娠期特异性肝病，其典型症状包括全身瘙痒和胆汁酸升高的生化证据。我们的研究旨在探讨ICP的存在与孕妇GDM、PE发生风险的相关性。方法:荟萃分析纳入10项符合条件的研究，包括17,688例ICP病例和1,386,771例对照，以评估ICP与先兆子痫(PE)和妊娠糖尿病(GDM)的相关性。有7项研究调查了ICP与PE之间的关系，9项研究评估了ICP与GDM之间的关系。所有符合条件的研究均从Pubmed、Web of Science和EBSCO数据库中筛选。结果:本荟萃分析结果显示，ICP显著增加PE(合并优势比OR: 2.56 95%CI: 2.27 2.88, I2异质性= 35%，p异质性= 0.16)和GDM(合并优势比OR: 2.28 95%CI: 1.69 3.07, I2异质性= 81%，p异质性< 0.001)的风险。在GDM的敏感性分析中，排除最大异质性研究不能改变结果(合并OR: 2.86 95%CI: 2.59 3.16, I2异质性= 0%，p异质性= 0.56)。结论:本荟萃分析显示妊娠期ICP与ICP增加PE和GDM风险密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.