{"title":"The Application of Quantitative Flow Ratio via 3-dimensional Coronary Angiography in Clinical Cardiology: A Review.","authors":"Ying Li, Hui Chen","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Fractional flow reserve (FFR) is a gold standard for the assessment of hemodynamic change during coronary stenosis, but it has several limitations such as high cost, the requirement of invasive pressure wire, and adverse drug reactions, which limit the wide application of FFR in clinical practice. In contrast, quantitative flow ratio (QFR) is a recently developed method for rapid calculation of FFR through 3-dimensional quantitative coronary angiography without the use of vasodilators and pressure wire. In this review we provide an updated summary of the principle of QFR, the correlation between QFR and FFR, and current applications of QFR in clinical cardiology. In conclusion, QFR provides a platform for functional evaluation of coronary stenoses based on angiographic data without invasive procedures; further development and optimization of QFR techniques will expand the application of QFR in clinical cardiology, ranging from diagnosis to coronary intervention to cardiac surgery, and benefit more patients.</p>","PeriodicalId":11379,"journal":{"name":"Discovery medicine","volume":"33 170","pages":"129-135"},"PeriodicalIF":2.0000,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Discovery medicine","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Fractional flow reserve (FFR) is a gold standard for the assessment of hemodynamic change during coronary stenosis, but it has several limitations such as high cost, the requirement of invasive pressure wire, and adverse drug reactions, which limit the wide application of FFR in clinical practice. In contrast, quantitative flow ratio (QFR) is a recently developed method for rapid calculation of FFR through 3-dimensional quantitative coronary angiography without the use of vasodilators and pressure wire. In this review we provide an updated summary of the principle of QFR, the correlation between QFR and FFR, and current applications of QFR in clinical cardiology. In conclusion, QFR provides a platform for functional evaluation of coronary stenoses based on angiographic data without invasive procedures; further development and optimization of QFR techniques will expand the application of QFR in clinical cardiology, ranging from diagnosis to coronary intervention to cardiac surgery, and benefit more patients.
期刊介绍：
Discovery Medicine publishes novel, provocative ideas and research findings that challenge conventional notions about disease mechanisms, diagnosis, treatment, or any of the life sciences subjects. It publishes cutting-edge, reliable, and authoritative information in all branches of life sciences but primarily in the following areas: Novel therapies and diagnostics (approved or experimental); innovative ideas, research technologies, and translational research that will give rise to the next generation of new drugs and therapies; breakthrough understanding of mechanism of disease, biology, and physiology; and commercialization of biomedical discoveries pertaining to the development of new drugs, therapies, medical devices, and research technology.
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