Enhancement of bioactivity and osseointegration in Ti-6Al-4V orthodontic mini-screws coated with calcium phosphate on the TiO2 nanotube layer.

IF 1.9 3区 医学 Q1 Dentistry
Korean Journal of Orthodontics Pub Date : 2022-11-25 Epub Date: 2022-08-23 DOI:10.4041/kjod22.118
Seon-Mi Byeon, Hye-Ji Kim, Min-Ho Lee, Tae-Sung Bae
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引用次数: 0

Abstract

Objective: This study evaluated the effect of cyclic pre-calcification treatment on the improvement of bioactivity and osseointegration of Ti-6Al-4V mini-screws.

Methods: The experimental groups were: an untreated group (UT), an anodized and heat-treated group (AH), and an anodized treatment followed by cyclic pre-calcification treatment group (ASPH). A bioactive material with calcium phosphate was coated on the mini-screws, and its effects on bioactivity and osseointegration were evaluated in in vitro and in vivo tests of following implantation in the rat tibia.

Results: As a result of immersing the ASPH group in simulated body fluid for 2 days, protrusions appearing in the initial stage of hydroxyapatite precipitation were observed. On the 3rd day, the protrusions became denser, other protrusions overlapped and grew on it, and the calcium and phosphorus concentrations increased. The removal torque values increased significantly in the following order: UT group (2.08 ± 0.67 N·cm), AH group (4.10 ± 0.72 N·cm), and ASPH group (6.58 ± 0.66 N·cm) with the ASPH group showing the highest value (p < 0.05). In the ASPH group, new bone was observed that was connected to the threads, and it was confirmed that a bony bridge connected to the adjacent bone was formed.

Conclusions: In conclusion, it was found that the surface treatment method used in the ASPH group improved the bioactivity and osseointegration of Ti-6Al-4V orthodontic mini-screws.

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在TiO2纳米管层上包覆磷酸钙对Ti-6Al-4V正畸微型螺钉生物活性和骨整合的增强作用。
目的:评价循环预钙化处理对Ti-6Al-4V微型螺钉生物活性和骨整合的改善作用。方法:实验组分为:未处理组(UT)、阳极氧化和热处理组(AH)、阳极氧化后循环预钙化处理组(ASPH)。将磷酸钙生物活性材料包被在微型螺钉上,并通过植入大鼠胫骨的体内和体外试验评估其对生物活性和骨整合的影响。结果:将ASPH组浸泡在模拟体液中2 d,观察到羟基磷灰石沉淀初期出现突起。第3天,突出物密度增大,其他突出物在其上重叠生长,钙、磷浓度升高。去除扭矩值依次为UT组(2.08±0.67 N·cm)、AH组(4.10±0.72 N·cm)、ASPH组(6.58±0.66 N·cm),其中ASPH组最大(p < 0.05)。在ASPH组中,观察到新骨与螺纹连接,证实与相邻骨形成骨桥。结论:ASPH组采用的表面处理方法提高了Ti-6Al-4V正畸微型螺钉的生物活性和骨整合性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Korean Journal of Orthodontics
Korean Journal of Orthodontics Dentistry-Orthodontics
CiteScore
2.60
自引率
10.50%
发文量
48
审稿时长
3 months
期刊介绍: The Korean Journal of Orthodontics (KJO) is an international, open access, peer reviewed journal published in January, March, May, July, September, and November each year. It was first launched in 1970 and, as the official scientific publication of Korean Association of Orthodontists, KJO aims to publish high quality clinical and scientific original research papers in all areas related to orthodontics and dentofacial orthopedics. Specifically, its interest focuses on evidence-based investigations of contemporary diagnostic procedures and treatment techniques, expanding to significant clinical reports of diverse treatment approaches. The scope of KJO covers all areas of orthodontics and dentofacial orthopedics including successful diagnostic procedures and treatment planning, growth and development of the face and its clinical implications, appliance designs, biomechanics, TMJ disorders and adult treatment. Specifically, its latest interest focuses on skeletal anchorage devices, orthodontic appliance and biomaterials, 3 dimensional imaging techniques utilized for dentofacial diagnosis and treatment planning, and orthognathic surgery to correct skeletal disharmony in association of orthodontic treatment.
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