Small Biopsy and Cytology of Pulmonary Neuroendocrine Neoplasms: Brief Overview of Classification, Immunohistochemistry, Molecular Profiles, and World Health Organization Updates.

IF 5.1 2区医学 Q1 PATHOLOGY

Advances In Anatomic Pathology Pub Date : 2022-11-01 Epub Date: 2022-09-02 DOI:10.1097/PAP.0000000000000360

Simon Sung, Jonas J Heymann, Michelle Garlin Politis, Marina K Baine, Natasha Rekhtman, Anjali Saqi

引用次数: 1

Abstract

Pulmonary neuroendocrine neoplasms comprise ~20% of all lung tumors. Typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma represent the 4 major distinct subtypes recognized on resections. This review provides a brief overview of the cytomorphologic features and the 2021 World Health Organization classification of these tumor types on small biopsy and cytology specimens. Also discussed are the role of immunohistochemistry in the diagnosis and molecular signatures of pulmonary neuroendocrine tumors.

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肺神经内分泌肿瘤的小活检和细胞学：分类、免疫组织化学、分子图谱和世界卫生组织更新的简要概述。

肺神经内分泌肿瘤约占所有肺肿瘤的20%。典型类癌、非典型类癌、小细胞癌和大细胞神经内分泌癌是切除术中公认的4种主要的不同亚型。这篇综述简要概述了细胞形态学特征和2021年世界卫生组织在小型活检和细胞学标本上对这些肿瘤类型的分类。还讨论了免疫组织化学在肺神经内分泌肿瘤诊断和分子特征中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances In Anatomic Pathology 医学-病理学

CiteScore

10.30

自引率

3.00%

发文量

审稿时长

>12 weeks

期刊介绍： Advances in Anatomic Pathology provides targeted coverage of the key developments in anatomic and surgical pathology. It covers subjects ranging from basic morphology to the most advanced molecular biology techniques. The journal selects and efficiently communicates the most important information from recent world literature and offers invaluable assistance in managing the increasing flow of information in pathology.