Osteoclast biology in the single-cell era.

IF 5 3区医学 Q2 IMMUNOLOGY

Inflammation and Regeneration Pub Date : 2022-09-02 DOI:10.1186/s41232-022-00213-x

Masayuki Tsukasaki, Hiroshi Takayanagi

引用次数: 7

Abstract

Osteoclasts, the only cells that can resorb bone, play a central role in bone homeostasis as well as bone damage under pathological conditions such as osteoporosis, arthritis, periodontitis, and bone metastasis. Recent studies using single-cell technologies have uncovered the regulatory mechanisms underlying osteoclastogenesis at unprecedented resolution and shed light on the possibility that there is heterogeneity in the origin, function, and fate of osteoclast-lineage cells. Here, we discuss the current advances and emerging concepts in osteoclast biology.

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单细胞时代的破骨细胞生物学。

破骨细胞是唯一能够吸收骨的细胞，在骨质疏松、关节炎、牙周炎和骨转移等病理条件下的骨稳态和骨损伤中起着核心作用。最近使用单细胞技术的研究以前所未有的分辨率揭示了破骨细胞发生的调节机制，并揭示了破骨细胞谱系细胞的起源、功能和命运存在异质性的可能性。在这里，我们讨论了破骨细胞生物学的最新进展和新概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammation and Regeneration Multiple-

CiteScore

11.10

自引率

1.20%

发文量

审稿时长

11 weeks

期刊介绍： Inflammation and Regeneration is the official journal of the Japanese Society of Inflammation and Regeneration (JSIR). This journal provides an open access forum which covers a wide range of scientific topics in the basic and clinical researches on inflammation and regenerative medicine. It also covers investigations of infectious diseases, including COVID-19 and other emerging infectious diseases, which involve the inflammatory responses. Inflammation and Regeneration publishes papers in the following categories: research article, note, rapid communication, case report, review and clinical drug evaluation.