The Treatment of Substance Use Disorders: Recent Developments and New Perspectives.

IF 2.3 4区心理学 Q3 NEUROSCIENCES

Neuropsychobiology Pub Date : 2022-01-01 Epub Date: 2022-06-20 DOI:10.1159/000525268

Annika Rosenthal, Claudia Ebrahimi, Friederike Wedemeyer, Nina Romanczuk-Seiferth, Anne Beck

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引用次数: 5

Abstract

Substance-related disorders are complex psychiatric disorders that are characterized by continued consumption in spite of harmful consequences. Addiction affects various brain networks critically involved in learning, reward, and motivation, as well as inhibitory control. Currently applied therapeutic approaches aim at modification of behavior that ultimately leads to decrease of consumption or abstinence in individuals with substance use disorders. However, traditional treatment methods might benefit from recent neurobiological and cognitive neuroscientific research findings. Novel cognitive-behavioral approaches in the treatment of addictive behavior aim at enhancement of strategies to cope with stressful conditions as well as craving-inducing cues and target erroneous learning mechanisms, including cognitive bias modification, reconsolidation-based interventions, mindfulness-based interventions, virtual-reality-based cue exposure therapy as well as pharmacological augmentation strategies. This review discusses therapeutic strategies that target dysregulated neurocognitive processes associated with the development and maintenance of disordered substance use and may hold promise as effective treatments for substance-related disorders.

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药物使用障碍的治疗:最近的发展和新的观点。

物质相关障碍是复杂的精神障碍，其特点是不顾有害后果继续消费。成瘾会影响与学习、奖励、动机以及抑制控制有关的各种大脑网络。目前应用的治疗方法旨在改变行为，最终导致物质使用障碍患者减少消费或戒断。然而，传统的治疗方法可能受益于最近的神经生物学和认知神经科学的研究成果。在成瘾行为治疗中，新的认知行为方法旨在增强应对压力条件和诱导渴望的线索和针对错误学习机制的策略，包括认知偏见修正、基于重新巩固的干预、基于正念的干预、基于虚拟现实的线索暴露治疗以及药物增强策略。这篇综述讨论了针对与物质使用障碍的发展和维持相关的失调神经认知过程的治疗策略，并有望成为物质相关疾病的有效治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychobiology 医学-精神病学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.