[Contents of BDNF, miR-30a-5p and miR-122 during alcohol withdrawal syndrome].

Q3 Biochemistry, Genetics and Molecular Biology

Biomeditsinskaya khimiya Pub Date : 2022-06-01 DOI:10.18097/PBMC20226803218

D I Peregud, A I Korolkov, V Y Baronets, A S Lobacheva, M L Arkus, S A Igumnov, S V Pirozhkov, N N Terebilina

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引用次数: 0

Abstract

Some BDNF (brain-derived neurotrophic factor)-targeted microRNAs such as miR-30a-5p associate with alcohol dependence phenomenon however their relationship with AWS is not described. We aimed to measure serum BDNF concentration and relative content of miR-30a-5p over the course of alcohol abstinence and compare obtained results with clinics of AWS. Additionally, we studied relative serum content of miR-30a-5p, a microRNA which does not target BDNF but relates to alcohol use disorder. Serum BDNF concentration increased over the course of alcohol abstinence, contrary relative content of miR-122 but not miR-30a-5p decreased. Moreover, during AWS miR-122 but miR-30a-5p negatively correlated with serum BDNF concentrations. Relative content of miR-122 negatively correlated with depression and state anxiety levels on 8th day of abstinence. According to multiple regressions on 21st day of abstinence alcohol craving and cognitive disturbances may be predictors of serum BDNF concentration, and vice versa. Thus, serum BDNF concentration and relative content of miR-122 associate with some aspects of AWS clinics and may dynamically reflect AWS severity.

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[酒精戒断综合征期间BDNF、miR-30a-5p和miR-122的含量]。

一些BDNF(脑源性神经营养因子)靶向的microrna如miR-30a-5p与酒精依赖现象相关，但它们与AWS的关系尚未被描述。我们的目的是在戒酒过程中测量血清BDNF浓度和miR-30a-5p的相对含量，并将获得的结果与AWS的临床结果进行比较。此外，我们研究了miR-30a-5p的相对血清含量，miR-30a-5p是一种不靶向BDNF但与酒精使用障碍有关的microRNA。在戒酒过程中，血清BDNF浓度升高，miR-122的相对含量相反，但miR-30a-5p的相对含量未下降。此外，在AWS期间，miR-122和miR-30a-5p与血清BDNF浓度呈负相关。戒断第8天miR-122的相对含量与抑郁和状态焦虑水平呈负相关。戒酒第21天的多元回归结果表明，酒精渴望和认知障碍可能是血清BDNF浓度的预测因子，反之亦然。因此，血清BDNF浓度和miR-122的相对含量与AWS临床的某些方面相关，并可能动态反映AWS的严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).