Current status and development trend of miRNAs in osteoporosis-related research: A bibliometric analysis.

IF 1.7 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Folia histochemica et cytobiologica Pub Date : 2021-01-01 Epub Date: 2021-12-01 DOI:10.5603/FHC.a2021.0024

Li Yun, Lining Wang, Yalan Pan, Mengmin Liu, Qiuge Han, Jie Sun, Guanglu Yang, Jirimutu Xiao, Yang Guo, Yong Ma

{"title":"Current status and development trend of miRNAs in osteoporosis-related research: A bibliometric analysis.","authors":"Li Yun, Lining Wang, Yalan Pan, Mengmin Liu, Qiuge Han, Jie Sun, Guanglu Yang, Jirimutu Xiao, Yang Guo, Yong Ma","doi":"10.5603/FHC.a2021.0024","DOIUrl":null,"url":null,"abstract":"Introduction: The occurrence of osteoporosis (OP) has drawn considerable attention from scholars around the world due to the significant impacts thereof on the social economy and the quality of human life. OP research has been rapidly expanding since the inclusion of microRNAs (miRNAs) as critical regulators of gene-expression. However, despite the ability to evaluate miRNA gene therapy in OP being enhanced, there has been a scarcity of updated citation analyses that reflect such developments. In the present study, through bibliometric analysis, the global research activity and trends in regard to the relationship between OP and miRNAs were reviewed.Methods: Publications related to miRNA and OP from 2000 to 2021 were retrieved via Web of Science (WoS). The data included publication years, countries, journals, institutions, authors and keywords, and were sorted and summarized by bibliometrics, before being visually analyzed through VOS Viewer.Results: In the past five years, 599 articles have been published, with said studies accounting for 79.11% of all relevant documents, indicating the increased interest in the present research topic. The country with the highest contribution rate was China, and the publication rate of Journal of Bone and Mineral Research was the highest, followed by Bone. The institutions with the highest contribution rate were Nanjing Medical University. The most frequently occurring keywords were clustered into five groups. The research area of the first group described that circulating miRNA would be a potential biomarker for postmenopausal osteoporosis (PMOP). The remaining four groups involved the influences of miRNAs and exosomes on the osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs), and the interactions of lncRNA and miRNA with OP.Conclusions: The results of the present study will expand the research on miRNAs and OP. The research direction with the highest frequency was the miRNAs acting on osteoblasts and osteoclasts. The influence of miRNAs carried by exosomes on the differentiation of MSCs might become an effective method for OP cell-free treatment.","PeriodicalId":12322,"journal":{"name":"Folia histochemica et cytobiologica","volume":"59 4","pages":"203-211"},"PeriodicalIF":1.7000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Folia histochemica et cytobiologica","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.5603/FHC.a2021.0024","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/12/1 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 4

Abstract

Introduction: The occurrence of osteoporosis (OP) has drawn considerable attention from scholars around the world due to the significant impacts thereof on the social economy and the quality of human life. OP research has been rapidly expanding since the inclusion of microRNAs (miRNAs) as critical regulators of gene-expression. However, despite the ability to evaluate miRNA gene therapy in OP being enhanced, there has been a scarcity of updated citation analyses that reflect such developments. In the present study, through bibliometric analysis, the global research activity and trends in regard to the relationship between OP and miRNAs were reviewed.

Methods: Publications related to miRNA and OP from 2000 to 2021 were retrieved via Web of Science (WoS). The data included publication years, countries, journals, institutions, authors and keywords, and were sorted and summarized by bibliometrics, before being visually analyzed through VOS Viewer.

Results: In the past five years, 599 articles have been published, with said studies accounting for 79.11% of all relevant documents, indicating the increased interest in the present research topic. The country with the highest contribution rate was China, and the publication rate of Journal of Bone and Mineral Research was the highest, followed by Bone. The institutions with the highest contribution rate were Nanjing Medical University. The most frequently occurring keywords were clustered into five groups. The research area of the first group described that circulating miRNA would be a potential biomarker for postmenopausal osteoporosis (PMOP). The remaining four groups involved the influences of miRNAs and exosomes on the osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs), and the interactions of lncRNA and miRNA with OP.

Conclusions: The results of the present study will expand the research on miRNAs and OP. The research direction with the highest frequency was the miRNAs acting on osteoblasts and osteoclasts. The influence of miRNAs carried by exosomes on the differentiation of MSCs might become an effective method for OP cell-free treatment.

查看原文本刊更多论文

mirna在骨质疏松相关研究中的现状及发展趋势:文献计量学分析。

骨质疏松症(osteoporosis, OP)的发生，因其对社会经济和人类生活质量的重大影响而受到世界各国学者的广泛关注。自从将microRNAs (miRNAs)作为基因表达的关键调控因子以来，OP研究一直在迅速扩大。然而，尽管评估miRNA基因治疗OP的能力得到了增强，但反映这一发展的最新引文分析却很缺乏。本研究通过文献计量学分析，综述了OP与mirna关系的全球研究活动和趋势。方法:通过Web of Science (WoS)检索2000 - 2021年与miRNA和OP相关的出版物。这些数据包括出版年份、国家、期刊、机构、作者和关键词，并通过文献计量学进行分类和汇总，然后通过VOS Viewer进行可视化分析。结果:近5年共发表论文599篇，占所有相关文献的79.11%，表明对当前研究课题的兴趣有所增加。贡献率最高的国家是中国，发表率最高的是Journal of Bone and Mineral Research，其次是Bone。贡献率最高的院校为南京医科大学。出现频率最高的关键词被分成五组。第一组的研究领域描述了循环miRNA可能是绝经后骨质疏松症(PMOP)的潜在生物标志物。其余四组涉及到miRNA和外泌体对间充质干细胞(MSCs)成骨和成脂分化的影响，以及lncRNA和miRNA与op的相互作用。结论:本研究结果将拓展miRNA和op的研究，频率最高的研究方向是miRNA作用于成骨细胞和破骨细胞。外泌体携带的mirna对MSCs分化的影响可能成为一种有效的无OP细胞治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Folia histochemica et cytobiologica 生物-生化与分子生物学

CiteScore

2.80

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： "Folia Histochemica et Cytobiologica" is an international, English-language journal publishing articles in the areas of histochemistry, cytochemistry and cell & tissue biology. "Folia Histochemica et Cytobiologica" was established in 1963 under the title: ‘Folia Histochemica et Cytochemica’ by the Polish Histochemical and Cytochemical Society as a journal devoted to the rapidly developing fields of histochemistry and cytochemistry. In 1984, the profile of the journal was broadened to accommodate papers dealing with cell and tissue biology, and the title was accordingly changed to "Folia Histochemica et Cytobiologica". "Folia Histochemica et Cytobiologica" is published quarterly, one volume a year, by the Polish Histochemical and Cytochemical Society.