Liposome-encapsulated glycyrrhizin alleviates hyperglycemia and glycation-induced iron-catalyzed oxidative reactions in streptozotocin-induced diabetic rats.

IF 4.3 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Liposome Research Pub Date : 2022-12-01 Epub Date: 2022-02-15 DOI:10.1080/08982104.2022.2036756

Subhrojit Sen

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引用次数: 3

Abstract

Glycyrrhizin, a bioactive constituent of Glycyrrhiza glabra has been reported to ameliorate diabetes. Here, the effects of liposome-encapsulated glycyrrhizin on STZ-induced diabetes and associated oxidative stress were investigated. Wistar rats were grouped as control (NC, received placebo), diabetic (DC, STZ-induced), diabetic treated with free glycyrrhizin (DTG, 3 i.v. doses, 1.6 mg/0.5 ml), empty liposomes (DTl, 3 i.v. doses), and liposome-encapsulated glycyrrhizin (DTbd, 3 i.v. doses, 1.6 mg/0.5 ml). Serum glucose, insulin, intraperitoneal glucose tolerance test and glycohemoglobin were estimated. Free iron and iron-mediated oxidative stress were examined. Histological examinations of the kidney and liver were performed. Liposomal-glycyrrhizin treatment caused significant improvement of hyperglycemia (DC vs. DTbd p < .05), glucose intolerance (DC vs. DTG p < .01 and DC vs. DTbd p < .05), insulin (DC vs. DTG p < .1, DTbd vs. DC p < .05 and DTbd vs. DTG p < .1) and glycohemoglobin (DC vs. DTG p < .1 and DC vs. DTbd p < .05) levels in the DTbd group. Alleviation of free iron release (DC vs. DTbd p < .05), lipid peroxidation (DC + H₂O₂ vs. DTbd + H₂O₂ p < .05), deoxyribose (DC + H₂O₂ vs. DTbd + H₂O₂, p < .05), and DNA degradation occurred in the DTbd group. The abnormalities of the kidney and liver were abolished in the DTbd group. The inhibitory effects were more pronounced compared to free glycyrrhizin. Liposome-encapsulated glycyrrhizin treatment caused inhibition of diabetic complications through its antioxidant effects and can be exploited for effective treatment of diabetes.

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脂质体包封的甘草酸减轻链脲佐菌素诱导的糖尿病大鼠的高血糖和糖基化诱导的铁催化氧化反应。

甘草酸是甘草酸的一种生物活性成分，据报道可以改善糖尿病。本文研究脂质体包封的甘草酸苷对stz诱导的糖尿病及相关氧化应激的影响。Wistar大鼠分为对照组(NC，安慰剂组)、糖尿病大鼠(DC, stz诱导组)、游离甘草酸(DTG, 3次静脉注射，1.6 mg/0.5 ml)、空脂质体(DTl, 3次静脉注射)和脂质体包封的甘草酸(DTbd, 3次静脉注射，1.6 mg/0.5 ml)治疗的糖尿病大鼠。测定血清葡萄糖、胰岛素、腹腔糖耐量及糖蛋白。检测游离铁和铁介导的氧化应激。对肾脏和肝脏进行组织学检查。脂质体-甘草酸治疗可显著改善高血糖(DC vs DTbd p p p p p p p p 2O2 vs DTbd + H2O2 p 2O2 vs DTbd + H2O2, p

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来源期刊

Journal of Liposome Research 生物-生化与分子生物学

CiteScore

10.50

自引率

2.30%

发文量

审稿时长

3 months

期刊介绍： The Journal of Liposome Research aims to publish original, high-quality, peer-reviewed research on the topic of liposomes and related systems, lipid-based delivery systems, lipid biology, and both synthetic and physical lipid chemistry. Reviews and commentaries or editorials are generally solicited and are editorially reviewed. The Journal also publishes abstracts and conference proceedings including those from the International Liposome Society. The scope of the Journal includes: Formulation and characterisation of systems Formulation engineering of systems Synthetic and physical lipid chemistry Lipid Biology Biomembranes Vaccines Emerging technologies and systems related to liposomes and vesicle type systems Developmental methodologies and new analytical techniques pertaining to the general area Pharmacokinetics, pharmacodynamics and biodistribution of systems Clinical applications. The Journal also publishes Special Issues focusing on particular topics and themes within the general scope of the Journal.