Relationships between the Fear of COVID-19 Scale and regional brain atrophy in mild cognitive impairment.

IF 3.8 4区医学 Q1 Medicine

Acta Neuropsychiatrica Pub Date : 2022-06-01 Epub Date: 2022-02-14 DOI:10.1017/neu.2022.7

Takumi Takahashi, Miho Ota, Yuriko Numata, Ayako Kitabatake, Kiyotaka Nemoto, Masashi Tamura, Masayuki Ide, Asaki Matsuzaki, Yuko Kaneda, Tetsuaki Arai

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引用次数: 4

Abstract

Background: Several studies have reported that the pandemic of coronavirus disease 2019 (COVID-19) influenced cognitive function in the elderly. However, the effect of COVID-19-related fear on brain atrophy has not been evaluated. In this study, we evaluated the relation between brain atrophy and the effect of COVID-19-related fear by analysing changes in brain volume over time using magnetic resonance imaging (MRI).

Methods: Participants were 25 Japanese patients with mild cognitive impairment (MCI) or subjective cognitive decline (SCD), who underwent 1.5-tesla MRI scan twice, once before and once after the pandemic outbreak of COVID-19, and the Fear of Coronavirus Disease 2019 Scale (FCV-19S) assessment during that period. We computed regional brain atrophy per day between the 1st and 2nd scan, and evaluated the relation between the FCV-19S scores and regional shrinkage.

Results: There was significant positive correlation between the total FCV-19S score and volume reduction per day in the right posterior cingulate cortex. Regarding the subscales of FCV-19S, we found significant positive correlation between factor 2 of the FCV-19S and shrinkage of the right posterior cingulate cortex.

Conclusions: There was positive correlation between the FCV-19S score and regional brain atrophy per day. Although it is already known that the psychological effects surrounding the COVID-19 pandemic cause cognitive function decline, our results further suggest that anxiety and fear related to COVID-19 cause regional brain atrophy.

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轻度认知障碍患者新冠肺炎恐惧量表与局部脑萎缩的关系

背景:多项研究报道了2019冠状病毒病(COVID-19)大流行对老年人认知功能的影响。然而，与covid -19相关的恐惧对脑萎缩的影响尚未得到评估。在这项研究中，我们通过使用磁共振成像(MRI)分析脑容量随时间的变化，评估了脑萎缩与covid -19相关恐惧效应之间的关系。方法:选取25例日本轻度认知障碍(MCI)或主观认知能力下降(SCD)患者，在2019冠状病毒病大流行爆发前后分别进行两次1.5特斯拉MRI扫描，并在此期间进行冠状病毒病恐惧量表(FCV-19S)评估。我们计算了第一次和第二次扫描之间每天的区域脑萎缩，并评估了FCV-19S评分与区域萎缩之间的关系。结果:FCV-19S总分与右侧后扣带皮层每日体积减少量呈正相关。在FCV-19S亚量表中，我们发现FCV-19S因子2与右侧后扣带皮质萎缩呈显著正相关。结论:FCV-19S评分与每天局部脑萎缩呈正相关。虽然我们已经知道COVID-19大流行的心理影响会导致认知功能下降，但我们的研究结果进一步表明，与COVID-19相关的焦虑和恐惧会导致局部脑萎缩。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neuropsychiatrica 医学-精神病学

CiteScore

8.50

自引率

5.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.