BRAIN AND EYE AS POTENTIAL TARGETS FOR IONIZING RADIATION IMPACT. PART III / FEATURES MORPHOMETRIC RETINAL PARAMETERS, AMPLITUDE AND LATENCY COMPONENTS OF VISUAL EVOKED POTENTIAL IN RADIATION EXPOSED IN UTERO.

T F Babenko, K M Loganovsky, T K Loganovska, N V Medvedovska, O O Kolosynska, N A Garkava, K V Kuts, K Yu Antipchuk, I V Perchuk, G Yu Kreinis, R Yu Dorichevska, Yu V Yefimova, P A Fedirko
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引用次数: 0

Abstract

One of the current problems of modern radiobiology is determine the characteristics of the manifestation of radiation-induced effects not only at different dose loads, but also at different stages of development of the organism. In previous reports, we have summarized available evidence that at certain ages there is a comparative acceleration of radiation-induced pathological changes in the eye and brain, and the study and assessment of the risk of possible ophthalmic and neurological pathology in remote periods after contamination of radioactive areas. Data of irradiated in utero individuals are possible on the basis of observation of the state of the visual analyzer in persons who underwent intrauterine irradiation in 1986. Therefore, a parallel study of retinal morphometric parameters, amplitude and latency of components of evoked visual potentials in irradiated in utero individuals was performed.

Objective: to evaluate the retinal morphometric parameters, amplitude and latency components of the evoked visual potentials in intrauterine irradiated persons.

Materials and methods: The results of surveys of 16 people irradiated in utero in the aftermath of the Chornobyl disaster were used; the comparison group were residents of Kyiv of the corresponding age (25 people). Optical coherence tomography was performed on a Cirrus HD-OCT, Macular Cube 512x128 study technique was used. At the same time, the study of visual evoked potentials on the inverted pattern was performed, and occipital leads wereanalyzed. Visual evoked potentials were recorded on a reversible chess pattern (VEP) - an electrophysiological test, which is a visual response to a sharp change in image contrast when presenting a reversible image of a chessboard.

Results: In those irradiated in utero at the age of 22-25 years, there was a probable increase in retinal thickness in the fovea, there was a tendency to increase the thickness of the retina in the areas around the fovea. When recording visual evoked potentials on a reversible chess pattern in this group, there was a tendency to decrease the amplitudes of components (N75, P100, N145, P200) in the right and left parieto-occipital areas and asymmetric changes in latency of these components.

Conclusions: Early changes of fovea recorded in OCT and decreasing amplitudes of components of visual evoked potentials on the reversible chess pattern at the age of 22 25 years may indicate a risk of development in patients irradiated in utero, early age-related macular degeneration, as well as increased risk and increased risk structures of the visual analyzer.

大脑和眼睛是电离辐射影响的潜在目标。第三部分介绍了子宫内辐射下视网膜形态学参数、视诱发电位振幅和潜伏期成分。
现代放射生物学目前面临的问题之一是确定辐射诱导效应在不同剂量负荷下的表现特征,以及在生物体发育的不同阶段。在以前的报告中,我们总结了现有的证据,表明在某些年龄,辐射引起的眼睛和大脑的病理变化相对加速,并研究和评估了放射性区域污染后较长时间内可能发生的眼科和神经病理的风险。根据对1986年接受宫内辐照的人的视觉分析仪状态的观察,可以获得宫内辐照个体的数据。因此,我们对子宫内受辐射个体的视网膜形态测量参数、诱发视觉电位分量的振幅和潜伏期进行了平行研究。目的:评价宫内照射患者视网膜诱发视觉电位的形态参数、振幅和潜伏期分量。材料和方法:使用了对切尔诺贝利灾难后子宫内受辐射的16人的调查结果;对照组为相应年龄的基辅居民(25人)。在Cirrus HD-OCT上进行光学相干断层扫描,使用黄斑立方体512x128研究技术。同时对倒立模式下的视觉诱发电位进行了研究,并对枕部导联进行了分析。视觉诱发电位被记录在一个可逆的象棋图案(VEP)上,这是一种电生理测试,它是当呈现一个可逆的棋盘图像时,对图像对比度急剧变化的视觉反应。结果:22 ~ 25岁子宫内受辐照者,视网膜中央窝厚度可能增加,中央窝周围有增加视网膜厚度的趋势。在可逆象棋模式下记录视觉诱发电位时,右脑和左脑顶枕区N75、P100、N145、P200分量的振幅有降低的趋势,且这些分量的潜伏期变化不对称。结论:在22 - 25岁的可逆性棋谱上,OCT记录的早期中央凹变化和视觉诱发电位分量振幅的下降可能提示子宫内辐照患者存在发育风险、早期年龄相关性黄斑变性,以及视觉分析者的风险增加和风险结构增加。
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Problemy radiatsiinoi medytsyny ta radiobiolohii
Problemy radiatsiinoi medytsyny ta radiobiolohii Medicine-Radiology, Nuclear Medicine and Imaging
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