Development of a high-performance liquid chromatography method to assess bisphenol F levels in milk.

IF 1.8 Q3 FOOD SCIENCE & TECHNOLOGY

Italian Journal of Food Safety Pub Date : 2021-12-13 eCollection Date: 2021-11-22 DOI:10.4081/ijfs.2021.9975

Serena Santonicola, Maria Carmela Ferrante, Giampaolo Colavita, Raffaelina Mercogliano

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Abstract

Bisphenol F (BPF) is a bisphenol A (BPA) analogue. As an endocrine disruptor, BPF shows a similar BPA hormonal activity and greater endocrine effects. To assess BPF levels in milk a selective method based on solvent extraction with acetonitrile, solid-phase extraction (SPE), high-performance liquid chromatography with fluorescence detection (HPLC-FD) system, was developed. The method showed high recovery values (from 97.60 to 107.16%), and good detection and quantification limits (LOD=0.03 μg/L; LOQ=0.1 μg/L). To validate the analytical method, quantitative analyses of n.20 milk samples of whole milk were preliminarily carried out applying a monitoring system based on the control of different stages of pasteurized whole milk processing at a dairy company. The proposed method is simple, sensitive, and might be suitable to detect BPF residues in milk processing. At the dairy company, the occurrence of BPF levels ranging from

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开发评估牛奶中双酚 F 含量的高效液相色谱法。

双酚 F（BPF）是双酚 A（BPA）的类似物。作为一种内分泌干扰物，BPF 表现出与双酚 A 相似的激素活性和更大的内分泌影响。为了评估牛奶中的 BPF 含量，我们开发了一种基于乙腈溶剂萃取、固相萃取 (SPE)、高效液相色谱-荧光检测 (HPLC-FD) 系统的选择性方法。该方法回收率高（97.60%-107.16%），检出限和定量限良好（LOD=0.03 μg/L；LOQ=0.1 μg/L）。为了验证该分析方法的有效性，在一家乳品公司对巴氏杀菌全脂牛奶加工的不同阶段进行控制的基础上，应用监测系统对n.20个全脂牛奶样品进行了初步定量分析。所建议的方法简单、灵敏，可能适用于检测牛奶加工过程中的 BPF 残留。在该乳品公司，BPF 含量范围为

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来源期刊

Italian Journal of Food Safety FOOD SCIENCE & TECHNOLOGY-

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Food Safety (IJFS) is the official journal of the Italian Association of Veterinary Food Hygienists (AIVI). The Journal addresses veterinary food hygienists, specialists in the food industry and experts offering technical support and advice on food of animal origin. The Journal of Food Safety publishes original research papers concerning food safety and hygiene, animal health, zoonoses and food safety, food safety economics. Reviews, editorials, technical reports, brief notes, conference proceedings, letters to the Editor, book reviews are also welcome. Every article published in the Journal will be peer-reviewed by experts in the field and selected by members of the editorial board. The publication of manuscripts is subject to the approval of the Editor who has knowledge of the field discussed in the manuscript in accordance with the principles of Peer Review; referees will be selected from the Editorial Board or among qualified scientists of the international scientific community. Articles must be written in English and must adhere to the guidelines and details contained in the Instructions to Authors.