A Case of Complex Pulmonary Hypertension: the Importance of Diagnostic Investigation.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-01-08 eCollection Date: 2022-01-01 DOI:10.1177/11795484211073292

Aninka Saboe, Vani Marindani, Charlotte Johanna Cool, Hilman Syawaluddin, Hussein S Kartamihardja, Prayudi Santoso, Mohammad Rizki Akbar

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Abstract

Pulmonary hypertension (PH) encompasses several heterogeneous groups of multiple diseases characterized by abnormal pulmonary arterial blood pressure elevation. Unrepaired atrial septal defect (ASD) may be associated with pulmonary arterial hypertension (PAH), indicating pulmonary vascular remodeling. Furthermore, unrepaired ASD could also be associated with other conditions, such as left heart disease or thromboembolism, contributing to the disease progression. We present a case of a 61-years-old woman with complex PH comprising several etiologies, which are PAH due to unrepaired Secundum ASD, mitral regurgitation caused by mitral valve prolapse as a group 2 PH, pulmonary embolism (PE) which progress to chronic thromboembolism PH (CTEPH) and post-acute sequelae of SARS Cov-2. We highlighted the importance of diagnostic investigation in PH, which is crucial to avoid misdiagnosis and inappropriate treatment that could be detrimental for the patient.

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1例复杂肺动脉高压:诊断调查的重要性。

肺动脉高压(PH)包括以肺动脉血压异常升高为特征的几种异质性多种疾病。未修复的房间隔缺损(ASD)可能与肺动脉高压(PAH)相关，表明肺血管重构。此外，未修复的ASD也可能与其他疾病有关，如左心疾病或血栓栓塞，导致疾病进展。我们报告了一例61岁女性的复杂PH，包括多种病因，包括未修复的继发性ASD引起的PAH，二尖瓣脱垂引起的二尖瓣反流(2组PH)，肺栓塞(PE)进展为慢性血栓栓塞性PH (CTEPH)和SARS Cov-2急性后后遗症。我们强调了PH诊断调查的重要性，这对于避免可能对患者有害的误诊和不适当的治疗至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.