Cholecystokinin B receptor gene polymorphism (rs2941026) is associated with anxious personality and suicidal thoughts in a longitudinal study.

IF 3.8 4区 医学 Q1 Medicine
Acta Neuropsychiatrica Pub Date : 2022-08-01 Epub Date: 2021-12-20 DOI:10.1017/neu.2021.41
Aneth Lvovs, Denis Matrov, Triin Kurrikoff, Toomas Veidebaum, Jaanus Harro
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引用次数: 0

Abstract

Objectives: Cholecystokinin is a neuropeptide with a role in the neurobiology of adaptive behaviour that is implicated in anxiety disorders, while the underlying mechanisms currently remain insufficiently explained. The rs2941026 variation in the cholecystokinin B receptor gene has previously been associated with trait anxiety. Our aim was to investigate associations between the CCKB receptor gene polymorphism rs2941026 with anxiety, personality, depressiveness and suicidality in a longitudinal study of late adolescence and early adulthood.

Methods: We used reports on trait and state anxiety, depressiveness and suicidal thoughts, as well as Affective Neuroscience Personality Scales, from the two birth cohorts of the Estonian Children Personality, Behaviour and Health Study. We measured associations between the CCKBR gene rs2941026 and anxiety-related phenotypes both longitudinally and cross-sectionally at ages 15, 18, 25 and 33.

Results: Homozygosity for both alleles of the CCKBR rs2941026 was associated with higher trait and state anxiety in the longitudinal analysis. Cross-sectional comparisons were statistically significant at ages 18 and 25 for trait anxiety and at ages 25 and 33 for state anxiety. Higher depressiveness and suicidal thoughts were associated with the A/A genotype at age 18. Additionally, homozygosity for the A-allele was related to higher FEAR and SADNESS in the Affective Neuroscience Personality Scales. The genotype effects were more apparent in females, who displayed higher levels of negative affect overall.

Conclusions: CCKBR genotype is persistently associated with negative affect in adolescence and young adulthood. The association of the CCKBR rs2941026 genotype with anxiety-related phenotypes is more pronounced in females.

在一项纵向研究中,胆囊收缩素B受体基因多态性(rs2941026)与焦虑人格和自杀念头有关。
目的:胆囊收缩素是一种神经肽,在焦虑障碍中涉及的适应性行为的神经生物学中起作用,而其潜在机制目前仍未得到充分解释。胆囊收缩素B受体基因的rs2941026变异此前被认为与特质焦虑有关。我们的目的是研究CCKB受体基因多态性rs2941026与青春期晚期和成年早期的焦虑、人格、抑郁和自杀之间的关系。方法:我们使用来自爱沙尼亚儿童人格、行为和健康研究的两个出生队列的特质和状态焦虑、抑郁和自杀念头的报告,以及情感神经科学人格量表。在15岁、18岁、25岁和33岁时,我们测量了CCKBR基因rs2941026与焦虑相关表型之间的纵向和横断面相关性。结果:在纵向分析中,CCKBR rs2941026两个等位基因的纯合性与较高的性状和状态焦虑相关。横断面比较在18岁和25岁的特质焦虑和25岁和33岁的状态焦虑中具有统计学意义。更高的抑郁和自杀想法与18岁时的A/A基因型有关。此外,a等位基因的纯合性与情感神经科学人格量表中较高的恐惧和悲伤有关。基因型的影响在女性身上更为明显,她们总体上表现出更高水平的负面影响。结论:CCKBR基因型与青春期和青年期的负面情绪持续相关。CCKBR rs2941026基因型与焦虑相关表型的关联在女性中更为明显。
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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica 医学-精神病学
CiteScore
8.50
自引率
5.30%
发文量
30
审稿时长
6-12 weeks
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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