Acute toxicity and metabolism of pesticides in birds.

IF 1.5 4区 农林科学 Q2 ENTOMOLOGY
Toshiyuki Katagi, Takuo Fujisawa
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引用次数: 4

Abstract

The median lethal dose of pesticide in acute oral toxicity, used as a conservative index in avian risk assessment, varies by the species with differences of less than one order of magnitude, depending on body size, feeding habit, and metabolic enzyme activity. The profiles of pesticide metabolism in birds with characteristic conjugations are basically common to those in mammals, but less information is available on their relevant enzymes. The higher toxicity of some pesticides in birds than in mammals is due to the lower activity of avian metabolic enzymes. The bioaccumulation in birds is limited for very hydrophobic pesticides resistant to metabolic degradation. Several in silico approaches using the descriptors of a pesticide molecule have recently been employed to estimate the profiles of acute oral toxicity and bioaccumulation.

Abstract Image

农药对鸟类的急性毒性和代谢。
农药急性口服毒性致死剂量中位数作为鸟类风险评估的保守指标,因体型、摄食习惯和代谢酶活性的不同,在不同物种间差异小于一个数量级。具有特征偶联的鸟类的农药代谢谱与哺乳动物基本相同,但有关其相关酶的信息较少。某些农药对鸟类的毒性高于对哺乳动物的毒性是由于鸟类代谢酶的活性较低。抗代谢降解的疏水性农药在鸟类中的生物积累有限。几种使用农药分子描述符的计算机方法最近被用于估计急性口服毒性和生物积累的概况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Pesticide Science
Journal of Pesticide Science 农林科学-昆虫学
CiteScore
4.30
自引率
4.20%
发文量
28
审稿时长
18-36 weeks
期刊介绍: The Journal of Pesticide Science publishes the results of original research regarding the chemistry and biochemistry of pesticides including bio-based materials. It also covers their metabolism, toxicology, environmental fate and formulation.
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