Bioactive compounds from an endophytic fungi Nigrospora aurantiaca.

IF 3.4 3区生物学 Q1 Agricultural and Biological Sciences

Botanical Studies Pub Date : 2021-10-26 DOI:10.1186/s40529-021-00324-7

Safwan Safwan, George Hsiao, Tzong-Huei Lee, Ching-Kuo Lee

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Abstract

Background: Many groups of fungi live as an endophyte in plants. Both published and undiscovered bioactive compounds can be found in endophytic fungi. Various biological activities of bioactive compounds from endophytic fungi had been reported, including anti-inflammatory and anticancerous effects. The chemical investigation of biologically active compounds from endophytic fungi Melaleuca leucadendra Linn. have not yet been stated.

Results: One new compound, namely nigaurdiol (1), along with five known compounds, xyloketal K (2), bostrycin (3), deoxybostrycin (4), xylanthraquinone (5), and ergosterol (6), were isolated from the Melaleuca leucadendra Linn. associated fungal strain Nigrospora aurantiaca ^#TMU062. Their chemical structures were elucidated by spectroscopic data and compared with literature. All isolated compounds were evaluated for inhibitory effect of NO production in LPS-activated microglial BV-2 cells.

Conclusions: Compound 6 exhibited considerable inhibitory effect on NO production with IC₅₀ values of 7.2 ± 1.4 µM and the survival rate of the cells was 90.8 ± 6.7% at the concentration of 10 µM.

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内生真菌 Nigrospora aurantiaca 的生物活性化合物。

背景：许多真菌以内生菌的形式生活在植物中。内生真菌中既有已发现的生物活性化合物，也有尚未发现的生物活性化合物。内生真菌中的生物活性化合物具有多种生物活性，包括抗炎和抗癌作用。关于内生真菌 Melaleuca leucadendra Linn：从 Melaleuca leucadendra Linn.相关真菌菌株 Nigrospora aurantiaca #TMU062 中分离出一种新化合物，即 nigaurdiol (1)，以及五种已知化合物，即 xyloketal K (2)、bostrycin (3)、deoxybostrycin (4)、xylanthraquinone (5) 和 ergosterol (6)。通过光谱数据阐明了它们的化学结构，并与文献进行了比较。评估了所有分离化合物对 LPS 激活的小胶质细胞 BV-2 中 NO 生成的抑制作用：结论：化合物 6 对 NO 的产生有相当大的抑制作用，IC50 值为 7.2 ± 1.4 µM，浓度为 10 µM 时，细胞存活率为 90.8 ± 6.7%。

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来源期刊

Botanical Studies 生物-植物科学

CiteScore

5.50

自引率

2.90%

发文量

审稿时长

2.4 months

期刊介绍： Botanical Studies is an open access journal that encompasses all aspects of botany, including but not limited to taxonomy, morphology, development, genetics, evolution, reproduction, systematics, and biodiversity of all plant groups, algae, and fungi. The journal is affiliated with the Institute of Plant and Microbial Biology, Academia Sinica, Taiwan.