High Levels of LINC01140 Expression Predict a Good Prognosis and Improve Radiotherapy in Sarcoma Patients.

IF 1.5 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Critical Reviews in Eukaryotic Gene Expression Pub Date : 2021-01-01 DOI:10.1615/CritRevEukaryotGeneExpr.2021038597

Xueyuan Hu, Weiwei Han, Ning Lou

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引用次数: 5

Abstract

Long intergenic non-protein coding RNA has an important biological role in tumors. But, LINC01140 in sarcoma has not been studied yet. This study investigates the expression and prognosis role of LINC01140 in sarcoma. LINC01140 was lower in metastatic sarcoma, and low LINC01140 expression predicted poor overall survival, disease-free survival, and disease-specific survival in sarcoma. High LINC01140 expression and radiotherapy could promote survival of sarcoma. Gene set enrichment analysis showed LINC01140 was involved in interferon-gamma response, epithelial-mesenchymal transition, the interaction between cytokine receptors, and cholesterol homeostasis. Gene ontology enrichment analysis showed LINC01140 was involved in immunity, fatty acid metabolism, amino acid metabolism, cell division, serine/threonine-protein kinase. LINC01140 expression was negatively correlated with various epithelial-mesenchymal transition factors and positively correlated with the expression of anti-cancer factor hypermethylated-in-cancer 1. These results confirmed that LINC01140 may be a potential novel prognostic molecule in sarcoma.

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高水平的LINC01140表达预示着肉瘤患者的良好预后和改善放疗

长基因间非蛋白编码RNA在肿瘤中具有重要的生物学作用。但是，LINC01140在肉瘤中的作用尚未得到研究。本研究探讨LINC01140在肉瘤中的表达及预后作用。LINC01140在转移性肉瘤中的表达较低，低表达预示着肉瘤的总生存期、无病生存期和疾病特异性生存期较差。LINC01140高表达和放疗可促进肉瘤的生存。基因集富集分析显示，LINC01140参与干扰素- γ反应、上皮-间质转化、细胞因子受体之间的相互作用和胆固醇稳态。基因本体富集分析表明，LINC01140参与免疫、脂肪酸代谢、氨基酸代谢、细胞分裂、丝氨酸/苏氨酸蛋白激酶等。LINC01140的表达与多种上皮-间质转化因子呈负相关，与抗癌因子高甲基化-in-cancer 1的表达呈正相关。这些结果证实LINC01140可能是一种潜在的新型肉瘤预后分子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Eukaryotic Gene Expression 生物-生物工程与应用微生物

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource. Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.